Catalyst – solid sorbent – or support therefor: product or process – Catalyst or precursor therefor – Organic compound containing
Patent
1993-01-15
1994-05-03
Garvin, Patrick P.
Catalyst, solid sorbent, or support therefor: product or process
Catalyst or precursor therefor
Organic compound containing
502171, B01J 3102
Patent
active
053088204
ABSTRACT:
A catalyst for asymmetric induction is provided which comprises an amino acid amide derivative represented by the formula [I]: ##STR1## wherein R.sup.1 represents an isopropyl group, etc., R.sup.2 and R.sup.3 are the same or different and each represents a lower alkyl group, etc., R.sup.4 represents a chlorine atom, etc., R.sup.5, R.sup.6 and R.sup.7 are the same or different and each represents a hydrogen atom, etc., and * denotes an abosolute configuration of S or R, and a titanium (IV) alkoxide.
Optically active cyanohydrins are obtained in high yield and at high purity by addition of hydrogen cyanide to aldehyde compounds in the presence of the above mentioned catalyst.
REFERENCES:
A. Mori et al., "Peptide-Metal Complex . . . Catalyst. A Catalytic Enantioselective Cyanohydrin Synthesis", Tetrahedron Letters, vol. 32, No. 34, 1991 (no month available), pp. 4333-4336.
M. Hayashi et al., "Enantioselective Trimethylsilylcyanation of Some Aldehydes by Chiral Titanium Schiff's Base Complexes", J. Chem. Soc., Chem. Commun., 1991 (no month available), pp. 1752-1753.
Inoue et al., "Peptide-Metal Complex as an Asymmetric Catalyst. A Catalytic Enantioselective Cyanohydrin Synthesis," Tetrahedron Letters, vol. 32, No. 34, Aug. 19, 1991.
Inoue et al., "Asymmetric Addition of Hydrogen Cyanide to Substituted Benzaldehydes Catalyzed by a Synthetic Cyclic Peptide, Cyclo((S)-Phenylalanyl-(S)-Histidyl)," Bulletin of the Chemical Society of Japan, vol. 59, pp. 893-895, Mar. 1986.
Inoue et al., "A Novel Rate Enhancement in Titanium and Zirconium Alkoxide Mediated Cyano Group Transfers by the Addition of a Salicylal Type Schiff Base, dl-3-(2-Hydroxy-1-Naphthylidene)-Imino-.epsilon.-Caprolactam," Chemistry Letters, No. 1, pp. 145-148, 1991.
Inoue et al., "Peptide-Titanium Complex and Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehyde," Journal of the American Chemical Society, vol. 114, No. 21, pp. 7969-7975, 1992.
Inoue et al., "Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by .alpha.-Amino Acid Amides," Synlett, No. 5, pp. 427-428, May 1992.
Inoue Shohei
Mori Atsunori
Garvin Patrick P.
Sumitomo Chemical Company Limited
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