Catalyst and method for amide formation

Details Catalyst and method for amide formation Catalyst and method for amide formation

1998-12-17

2000-09-19

Carr, Deborah D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 68, C07C23100

Patent

active

06121471&

ABSTRACT:
The invention is a catalyst, the use of the catalyst and a method of using the catalyst in the formation of a compound with an amide bond. The catalyst is an HOBT derivative having the following formula (1): ##STR1## where R.sup.1 is a group bearing a positive charge at pH 5-7; where Y is a bond or a substituted or unsubstituted alkylene chain containing 1-10 carbon atoms and 0-2 heteroatoms selected from the group consisting of N, S and O; and where X is a linker group selected from --CO-- or --SO.sub.2 --. In the method, an amine, a carboxylic acid, an amide coupling agent and a catalyst of formula (1) are reacted for a time sufficient to produce an amide bond between the amine and the carboxylic acid. Thereafter, the compound containing the amide bond is isolated.

REFERENCES:
patent: 3725380 (1973-04-01), Konig et al.
Pop. et al.,J. Org. Chem., vol. 62, No. 8, pp. 1-15, 1997.
Pop, I.E., et al. Versatile Acylation of N-Nucleophiles Using a New Polymer-Supported 1-Hydroxybenzotriazole Derivative. J. Org. Chem. 1997, vol. 62, No. 8, pp. 1-15.

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