Cat-mouse heterohybridoma and gene fragment coding for constant

Details Cat-mouse heterohybridoma and gene fragment coding for constant Cat-mouse heterohybridoma and gene fragment coding for constant

1994-05-23

1996-04-02

Ziska, Suzanne E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

5303873, 5303871, C07H 2104, C07K 1600, C12P 2108

Patent

active

055041981

ABSTRACT:
A Gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin .lambda. chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin .kappa. chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin .gamma. chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
Science, vol. 229, Sep. 20, 1985, S. L. Morrison, "Transfectomas Provide el Chimeric Antibodies", pp. 1202-1207.
Trends in Biotechnology, vol. 6, No. 2, Feb. 1988, G. Williams, "Novel Antibody Reagents: Production and Potential", pp. 36-39, 42.
Proceedings of the Nat. Academy of Sciences of the USA, Oct. 1989, vol. 86, No. 19, Schneiderman et al., "Expression of 12 rabbit IgA C.sub.a genes as chimeric rabbit-mouse IgA antibodies".
Capra et al. in Antibody Structure and Molecular Immunology 36:3, 1975.
Chemical Abstracts 84; 1976 p. 424 84:103680k Capra et al.
Capra et al. Fed of Europ. Biochem. Societies, Ninth Meeting, vol. 36:3-18, 1974.

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