Cat kidney disease marker

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S019000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

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11227614

ABSTRACT:
In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

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Sequence searches, U.S. Appl. No. 11/227,614.
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Pamphlet of The Molecular Biology Society of Japan annual meeting 2001 (front page, p. 206 and p. 795).

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