Cat kidney disease marker

Details Cat kidney disease marker Cat kidney disease marker

2006-04-11

2006-04-11

Patterson, Jr., Charles L. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S019000, C435S320100, C435S252300, C536S023200, C530S387900

Reexamination Certificate

active

07026151

ABSTRACT:
In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

REFERENCES:
patent: 09-171019 (1994-06-01), None
patent: 10-132817 (1998-05-01), None
Miyazaki, J., et al., (2003) Biochem. J. 370, 101-110.
“Rat Kidney Carboxylesterase”The Journal of Biological Chemistryvol. 269, No. 47, Issue of Nov. 25, pp. 29688-29696, 1994 Yan et al.
Pamphlet of The Molecular Biology Society of Japan annual meeting 2001 (front page, p206 and p795).

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