Cast membrane structures for sample preparation

Details Cast membrane structures for sample preparation Cast membrane structures for sample preparation

1998-01-15

2000-04-11

Fortuna, Ana

Liquid purification or separation

Casing divided by membrane into sections having inlet

Energy recovery from treated liquid

21032184, 21050041, 21050036, 21050042, 21050035, 2105021, 21050029, 422101, 422 681, 422100, B01D 6300

Patent

active

060484578

ABSTRACT:
A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.

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Solid Phase Sciences for Pipet tips advertisement.

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