Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-04-01
2008-04-01
Page, Thurman K. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S210200, C514S231500, C514S245000, C514S253130, C514S254010, C514S330000, C514S423000, C554S080000
Reexamination Certificate
active
07351702
ABSTRACT:
This invention provides compounds of formula I:wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y;next to R3represents a single or double bond; Y is an electronegative leaving group; R2is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3is a group capable of fitting into the S2 subsite of a caspase enzyme; R4is a hydrogen or C1-6alkyl or R3and R4taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.
REFERENCES:
patent: 6800619 (2004-10-01), Charrier et al.
patent: WO98/16502 (1998-04-01), None
patent: WO99/56765 (1999-11-01), None
patent: WO 01/72707 (2001-10-01), None
Charrier Jean-Damien
Miller Andrew
Mortimore Michael
Studley John
Che Jennifer G.
Dixon Lisa A.
Nwaonicha Chukwuma
Page Thurman K.
Vertex Pharmaceuticals Incorporated
LandOfFree
Caspase inhibitors and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Caspase inhibitors and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Caspase inhibitors and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2799289