Caspase inhibitors and uses thereof

Details Caspase inhibitors and uses thereof Caspase inhibitors and uses thereof

2011-03-15

2011-03-15

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S156000

Reexamination Certificate

active

07906650

ABSTRACT:
This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula I:where R1, R2, and R3are as described herein, Ring A contains zero to two double bonds, each X is independently selected from nitrogen or carbon, at least one X in Ring A is a nitrogen, Ring A is optionally substituted as described, and may be fused to a saturated or unsaturated five to seven membered ring containing zero to three heteroatoms, and provided that when X3is a carbon, a substituent on X3is attached by an atom other than nitrogen.

REFERENCES:
patent: 5801148 (1998-09-01), Gyorkos et al.
patent: 7517987 (2009-04-01), Golec et al.
patent: 9816502 (1998-04-01), None

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