Caspase 9 activation and uses therefor

Details Caspase 9 activation and uses therefor Caspase 9 activation and uses therefor

2006-10-10

2006-10-10

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S024000, C435S212000, C424S094630, C514S018700

Reexamination Certificate

active

07118877

ABSTRACT:
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.

REFERENCES:
patent: 6114132 (2000-09-01), Desmarais et al.
patent: 6121416 (2000-09-01), Clark et al.
patent: 6221355 (2001-04-01), Dowdy
patent: 6271361 (2001-08-01), Alnemri et al.
patent: 6274318 (2001-08-01), Alnemri et al.
patent: 6342611 (2002-01-01), Weber et al.
patent: 6391575 (2002-05-01), Fritz et al.
patent: 6455296 (2002-09-01), Alnemri
patent: 2001/0016345 (2001-08-01), Alnemri
Hall et al., “Activation of the Herpes Simplex Virus Type I protease,” J Biol Chem 270(39):22697-22700, 1995.
Renatus et al., “Dimer formation drives the activation of the cell death protease caspase 9,” Proc Natl Acad Sci USA 98(25):14250-14255, 2001.
Principles of Biochemistry, Lehninger, ed., Chap. 16, pp. 441-445, Worth Publishers, Inc., New York, 1982.
Definitions of peptide and polypeptide, Merriam-Webster Online Dictionary, www.m-w.com, printed from the Internet on Sep. 2, 2004.
Definition of oligopeptide, MedicineNet.com on-line dictionary, http://www.medterms.com/script/main/hp.asp, printed from the Internet on Sep. 2, 2004.
Collins, “Sticky ions in biological systems,” Proc Natl Acad Sci USA 92:5553-5557, 1995.
Washabaugh et al., “The systematic characterization by aqueous column chromatography of solutes which affect protein solubility,” J Biol Chem 261(27):12477-12485, 1986.
Jeruzalmi et al. “Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme,” J Mol Biol 274:748-756, 1997.
C.H. Weber and C. Vincenz, “The death domain superfamily: a tale of two interfaces?”Trends in Biochemical Sciences,26(8): 475-481, 2001.
M. Renatus et al. “Dimer formation drives the activation of the cell death protease caspase 9,”PNAS98(25): 14250-14255, 2001.
M. Ru et al. “On the salt-induced activation of lyophilized enzymes in organic solvents: Effect of salt kosmotropicity on enzyme activity,”Journal of the American Chemical Society122(8): 1565-1571, 2000.
M. Cacace et al. “The Hofmeister series: salt and solvent effects on interfacial phenomena,”Quart. Rev. of Biophysics30: 241-277, 1997.
D. Hall and P. Darke. “Activation of the Herpes Simplex virus type 1 protease,”Journal of Biological Chemistry270(39): 22697-22700, 1995.
Nicholson et al. “Identification and inhibition of the ICE/CED-3 protease necessary for mammlian apoptosis,”Nature376: 37-43, 1995.
Current Protocols in Cell Biology,Chapter 18.
G. Smith et al. “Expression, preparation, and high-throughput screening of Caspase-8: discovery of redox-based and steroid diacid inhibition,”Arch. Biochem. Biophys.399(2): 195-205, 2002.
Boatright, K. et al., “A Unified Model for Apical Caspase Activation,” Molecular Cell, 529-541, Feb.11, 2003, Cell Press.
Collins, “Sticky Ions in Biological Systems,”Proc. Natl. Acad. Sci. USA,vol. 92, pp. 5553-5557, Jun. 1995.
Schmidt et al., “Dimerization and Activation of the Herpes Simplex Virus Type I Protease,”J. Biol. Chem.,vol. 272, No. 12, pp. 7732-7735, 1997.
Washabaugh et al., “The Systematic Characterization by Aqueous Column Chromatography of Solutes Which Affect Protein Stability,”J. Biol. Chem.,vol. 261, No. 27, pp. 12477-12485, 1986.

Affiliated with

Also associated with

Rating

Caspase 9 activation and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Caspase 9 activation and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Caspase 9 activation and uses therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3709822