Casein phosphopeptide, casein containing same and process for th

Details Casein phosphopeptide, casein containing same and process for th Casein phosphopeptide, casein containing same and process for th

1996-03-25

1998-11-10

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514775, 514902, 530324, 530360, 530416, 530417, 530420, 530419, 530427, 426539, A61K 3817, C07K 1447, A23T 310

Patent

active

058344276

ABSTRACT:
The present invention relates to a purified casein phosphopeptide(CPP) having a novel amino acid sequence and a purified casein including same wherein the 25th Arg from N-terminal in a conventional CPP is replaced by Cys, rendering the CPPs to forming a dimer by disulfide bond. In the corresponding DNA sequence, cytosine is replaced by thymine to cause the amino acid replacement from Arginine(Arg) to Cysteine(Cys). The CPP or the casein containing same has an improved ability of solubilizing minerals and absorbing thereof in animals. The CPP or the beta-casein H containing same can be added to foodstuffs, beverages, medication, cosmetics, feed in an effective amount of enhancing a mineral absorption in animals. An oral composition comprising the beta-casein H or the inventive CPP and a pharmaceutically acceptable carrier can reduce or relieve a dentinal hypersensitivity.

REFERENCES:
patent: 5085871 (1992-02-01), Horikawa et al.
patent: 5227154 (1993-07-01), Reynolds
patent: 5405756 (1995-04-01), Naito et al.
Patent Abstracts of Japan, vol. 18, No. 71 (C-1162), 1994, JP 4-88459 (Meiji Seika Kaisha Ltd.).
Dialog Abstract, Biosis No.:99229799. Stevenson et al. 1996. J. of Agricultural and Food Chemistry 44(9):2825-2828, 1996.

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