Casein peptides for alleviating or preventing aging of skin

Details Casein peptides for alleviating or preventing aging of skin Casein peptides for alleviating or preventing aging of skin

2001-06-13

2009-08-25

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S015800, C514S021800

Reexamination Certificate

active

07579315

ABSTRACT:
Provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing periodontal disease, wherein the peptide comprises an amino acid sequence present in an α-S2 casein precursor, said sequence comprising 3 or more amino acids, and not comprising at its N-terminus the N-terminal amino acids of the full α-S2 casein precursor. The peptide may alternatively be any peptide having an α-S2 casein fragment activity. Further provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing an effect of aging in skin, wherein the peptide comprises an amino acid sequence present in a n α-S2 casein precursor, said sequence comprising 3 or more amino acids, and not comprising at its N-terminus the N-terminal amino acid of the full α-S2 casein precursor. The peptide may alternatively be any peptide having an α-S2 casein fragment activity.

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Liu et al., “A Growth Factor Activity in Bovine Milk”, Biochemical Society Transactions, Colchester, Essex, GB, vol. 24, No. 3, p. 342S, (1996).
Yokyama et al., 1992, Peptide Inhibitors for Angiotensin I-Converting Enzyme from Thermolysin Digest of Dried Bonito,Biosci. Biotech. Biochem., 56(10), 1541-1545.
Matsui et al., 2002, Absorportion of Val-Tyr with in Vitro Angiotensin I-Converting Enzyme Inhibitory Activity into the Circulating Blood System of Mild Hypertensive Subjects,Biol. Pharm. Bull., 25(9) 1228-1230.

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