Casein derived peptides and uses thereof in therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S775000, C530S360000, C530S361000, C530S407000, C424S278100

Reexamination Certificate

active

07741274

ABSTRACT:
Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the oS1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases.

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[Attachment 1 ] NCBI Sequence Viewer (2007, updated) CAA42516, alpha-S1-casein, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=92, pp. 1-2.
[Attachment 2 ] NCBI Sequence Viewer (2007, updated) CAA55185, alpha-S1-casein, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=854086, pp. 1-2.
[Attachment 1 ] NCBI Sequence Viewer (2007, updated) P09115, alpha-S1-casein precusor, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=115651, pp. 1-2.
Hematopoiesis (2007, updated) “Hematopoiesis”, http://www.som.tulane.edu/classware/pathology/Krause/Blood/HP.html, p. 1.
Thrombopoiesis (2007, updated) “Thrombopoiesis”, http://www.tau.ac.il/˜inter05/throm.htm, p. 1.
Chabance et al., “Casein peptide release and passage to be blood in humans during digestion of milk or yogurt”,Biochimie, 80:155-165 (1998).
McSweeney et al., “Proteolytic specificity of chymosin on bovine alpha S1-casein”,J. Dairy Res., 60(3):401-412 (1993).

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