Casein derived peptides and uses thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Casein or caseinate

Reexamination Certificate

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C514S014800, C514S015800, C514S016700, C514S017400, C514S018700

Reexamination Certificate

active

07666996

ABSTRACT:
Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the αS1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases, alone or in combination with other peptides or blood cell stimulating factors.

REFERENCES:
patent: 3778426 (1973-12-01), Najjar et al.
patent: 4959455 (1990-09-01), Clark et al.
patent: 5846732 (1998-12-01), Collin et al.
patent: 6180761 (2001-01-01), Han et al.
patent: 6495344 (2002-12-01), Carr et al.
patent: 7183386 (2007-02-01), McCall et al.
patent: 2003/0195150 (2003-10-01), Reynolds et al.
patent: 2004/0002118 (2004-01-01), Smilansky
patent: 3476516 (2003-12-01), None
patent: WO 03/093308 (2003-11-01), None
Isma'eel et al. (2006) Screening for inherited thrombophilia might be warranted among Eastern Mediterranean sickle-Beta-0 thalassemia patients. J. Thromb. Thrombolysis. vol. 22, No. 2, pp. 121-123.
Saito et al. (2000) Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci. vol. 87, No. 7, pp. 1434-1440.
Hillaire-Buys et al. (1992) Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells. Mol. Cell. Biochem. vol. 109, No. 2, pp. 133-138.
Noah (2006) Genetic blood disorder, http://www.noah-health.org/en/blood/types/genblood.html, p. 1.
NCBI Sequence Viewer (2006) Casein B precursor (alpha-S1-casein), http://www.ncbi.nlm.nih.gov/entrez/ viewer.fcgi?db=protein&val=115648, pp. 1-3.
NCBI Sequence Viewer (2006) Alpha-S1-casein precursor http://www.ncbi.nlm.nih.gov/entrez/ viewer.fcgi?db=protein&val=115646, pp. 1-5.
NCBI Sequence Viewer (2006) Alpha-s1-casein precursor, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=115650, pp. 1-4.
NCBI Sequence Viewer (2006) casein alpha s1 isoform 1, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=4503085, pp. 1-3.
NCBI Sequence Viewer (2006) casein alpha s1 isoform 1, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val =68303569, pp. 1-3.
NCBI Sequence View (2006) Kappa-casein, http://www.ncbi.nlm.nih.gov/entrez/ viewer.fcgi?db=protein&val=186655, p. 1.
Thalassemia (2006) How can thalassemia be prevented, http://www.nhIbi.nih.gov/health/dci/Diseases/ Thalassemia/Thalassemia—Prevention.html, p. 1.
Kato et al. (1979) Changes of X-prolyl dipeptidyl-aminopeptidase activity in developing rat brain, Cell. Mol. Life Sci., vol. 35, No. 10, pp. 1329-1330.
Gouldsworthy et al. (1996) Application of a mass spectrometry sequencing technique for identifying peptides present in Cheddar cheese, Int. Dairy J., vol. 6, pp. 781-790.
Fiat et al. “Biologically Active Peptides From Milk Proteins With Emphasis on Two Examples Concerning Antithrombotic and Immunomodulating Activities”, J. Dairy. Sci., 76: 301-310, 1993.
Lahov et al. “Antibacterial and Immunostimulting Casein-Derived Substances From Milk: Casecidin, Isracidin Peptides”, Food and Chemical Toxicology, 34(1): 131-145, 1996.
Shimizu et al. “Emulsifying Properties of an N-Terminal Peptide Obtained From the Peptic Hydrolyzate of Alphas1-Casein”, Journal of Food Science, 49(4): 1117-1120, 1984.
von dem Borne et al. “Thrombopoietin: Modes of Action, Role in Platelet Disorders and New Drugs”, Academic Medical Center, Amsterdam.
Pahkala et al. “Decomposition of Milk Proteins During the Ripening of Cheese 1. Enzymatic Hydrolysis of Alpha-S Casein”, Meijeritieteellinen Aikakauskirja, 47(1): 39-47, 1989.
Kim et al. “Genetic Models for Non Insulin Dependent Diabetes Mellitus in Rodents”, Journal of Basic & Clinical Physiology & Pharmacology 9(2-4): 325-345, 1998.
Nolan et al. “Antiretroviral Prophylaxis of Perinatal HIV-1 Transmission and the Potential Impact of Antiretroviral Resistance”, JAIDS, 30: 216-229, 2002.
Marmor et al. “Homozygous and Heterozygous CCR5-Delta32 Genotypes are Associated with Resistance to HIV Infection”, JAIDS, 27: 472-481, 2001.
Sriwanthana et al. “HIV-Specific Cytotoxic T Lymphocytes, HLA-All, and Chemokine-Related Factors May Act Synergistically to Determine HIV Resistance in CCR Delta32-Negative Female Sex Workers in Chiang Rai, Northern Thailand”, Aids Research and Human Retroviruses, 17(8): 719-734, 2001.
Giannoukakis et al. “Gene and Cell Therapies for Diabetes Mellitus”, Biodrugs, 16(3): 149-173, 2002.
Yoon et al. “Cellular and Molecular Pathogenic Mechanisms of Isulin-Dependent Diabetes Mellitus”, Annals New York Academy of Science, pp. 200-211.
Notterpek et al. “Experimental Models of Peripheral Neuropathies”, Laboratory Animal Science 49(6): 588-599, 1999.
Wong et al. “Insulin-Dependent Diabetes Mellitus and its Animal Models”, Current Opinion in Immunology 11: 643-647, 1999.
Prud'homme “Gene Therapy of Autoimmune Diseases with Vectors Encoding Regulatory Cytokines or Inflammatory Cytokine Inhibitors”, The Journal of Gene Medicine 2: 222-232, 2000.
Kitts “Bioactive Substances in Food: Identification and Potential Uses”, Can. J. Physiol. Pharmacol., 72(4): 423-434, 1999. Abstract.
McSweeney et al. “Proteolytic Specificity of Chymosin on Bovine Alpha S1-Casein”, J. Dairy Res., 60(3): 401-412, 1993. Abstract.
Yvon et al. “Solubility of Peptides in Trichloroacetic Acid (TCA) Solutions. Hypothesis on the Precipitation Mechanism”, Int. J. Pept. Prot. Res., 34(3): 166-176, 1989. Abstract.
Laugesen et al. “The Influence of Connsumption of A1 Beta-Casein on Heart Disease and Type 1 Diabeties—The Authors Reply”, NZ Med. J., 16(1170): U295, 2003.
Rota et al. “Characterization of a Novel Coronavirus Associated With Severe Acute Respiratory Syndrome”, Science, 300(5624): 1394-1399, 2003.
Koczan et al. “Genomic Organization of the Bovine Alpha-S1 Casein Gene”, Nucleic Acids Res., 19(20): 5591-5596, 1991.
Meisel et al. “Bioactive Peptides Encrypted in Milk Proteins: Proteolytic Activation and Thropho-Functional Properties”, Antonie Van Leeuwenhoek, 76(1-4): 207-215, 1999. Abstract.
Groenen et al. “The Complete Sequence of the Gene Encoding Bovine Alpha S2-Casein”, Gene, 123(2): 187-193, 1993. Abstract.
Malkoski et al. “Kappacin, A Novel Antibacterial Peptide From Bovine Milk”, Antimicrob. Agents Chemother., 45(8): 2309-2315, 2001.
Michaelidou et al. “Isolation and Identification of Some Major Water-Soluble Peptides in Feta Cheese”, J. Dairy Sci., 81: 3109-3116, 1998.
Rattray et al. “Specificity of an Extracellular Proteinase FromBrevibacterium linensATCC 9174 on Bovine Alpha s1-Casein”, Applied and Environmetal Mircobiology, 62(2): 501-506, 1996.
Mercier et al. “Construction and Identification of Recombinant Plasmids Carrying cDNSs Coding for Ovine Alpha S1-, Alpha S2-, Beta-, Kappa-Casein and Beta-Lactoglobulin. Nucleotide Sequence of Alpha S1-Casein cDNA”, Biochimie, 67(9): 959-971, 1985. Abstract.
Exterkate et al. “Diversity of Call Envelope Proteinase Specificity Among Strains ofLactococcus Lactisand Its Relationship to Charge Characteristics of the Substrate-Binding Region”, Appl. Environ. Microbiol., 59(11): 3640-3647, 1993.
Nakajima-Adachi et al. “Determinant Analysis of IgE and IgG4 Antibodies and T Cells Specific for Bovine Aplha(s)1-Casein From the Same Patients Allergic to Cow's Milk: Existence of Alpha(s)1-Casein-Specific B Cells and T Cells Characteristic in Cow's-Milk Allergy”, J. Allergy Clin. Immunol., 101(5): 660-671, 1998. Abstract.
Pizzano et al. “Antipeptide Antibodies as Analy

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