Cartilage matrix protein and methods for use

Details Cartilage matrix protein and methods for use Cartilage matrix protein and methods for use

1995-06-05

1997-11-11

Wax, Robert A.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

424 111, 530357, 530350, A61K 4900, A61K 3806, A61K 3817, C07K 100

Patent

active

056860595

ABSTRACT:
DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their production and purification from transformed cells as well as their use as agents in therapeutics and clinical imaging. In addition, the invention disclosed a method for forming collagen fibrils using the chimeric polypeptide.

REFERENCES:
patent: 5043429 (1991-08-01), Zimmerman et al.
Argraves et al., Proc. Nat'l. Acad. Sci. USA 84:464, 1987.
Bonaldo et al., Biochemistry 29:1245, 1990.
Gerecke, "Two Alternative Forms of Type XII Collagen Molecules are Multidomain Structures Containing von Willebrand Factor A and Fibronectin Type III Repeats", Harvard University, Cambridge, Massachusetts, 1992.
Jenkins et al., J. Biol. Chem. 265:19624, 1990.
Kiss et al., J. Biol. Chem. 264:8126, 1989.
Kiss et al., Molecular and Cellular Biology, vol. 10, No. 5, Issued May, 1990, pp. 2432-2436.
Pareti et al., J. Biol. Chem. 28:13835, 1987.
Goetinck et al., Annals of the New York Academy of Sciences 559:29, 1990.
Stirpe et al., Development 107:23, 1989.
Tsonis et al., Exp. Eye Res. 46:753-764, 1988.
Tsonis et al., Biochem. Journal 254:623, 1988.
Louis et al. "Autoprocessing of the HIV-1 protease using . . . " Eur. J. Biochem. 199, 361-369. 1991.

Affiliated with

Also associated with

Rating

Cartilage matrix protein and methods for use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cartilage matrix protein and methods for use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cartilage matrix protein and methods for use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1226472