Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1986-07-30
1988-05-24
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
530395, 530840, 514824, 514825, A61K 3712, A61K 3702
Patent
active
047467290
ABSTRACT:
A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.
REFERENCES:
patent: 4402872 (1983-09-01), Bohn
patent: 4404194 (1983-09-01), Arala-Chaves
patent: 4604234 (1986-08-01), Fujii et al.
Nakajima et al., Journ. Biol. Chem. vol. 254, pp. 4027-4032, 1979.
Hawke et al., And. Biochem. 120,302-311 (1982).
"Bone Metastasis", Hall, Medical Publishers, 1981, pp. 153-154.
Brocks Dietrich
DiMuzio Michael T.
Kuettner Klaus E.
Tripier Dominique
Finnegan, Henderson Farabow, Garrett and Dunner
Nutter Nathan M.
Phillips Delbert R.
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