Cartilage degradation assay system

Details Cartilage degradation assay system Cartilage degradation assay system

1991-12-06

1994-02-08

Green, Randall L.

Surgery

Truss

Pad

128760, 623 16, A61B 1000, A61B 500, A61F 228

Patent

active

052841553

ABSTRACT:
Methods for diagnosing and monitoring arthritic disease with an inflammatory joint component in a mammal are described. The methods comprise (a) obtaining a sample of powdered cartilage or synovial fluid from the mammal, (b) mixing the sample with powdered cartilage, or protein that is detectably labeled, (c) determining the amount of label released from the powdered cartilage or protein, the amount being indicative of the level of protease activity, and (d) comparing the level to a standard, or to the level obtained from a sample taken at another time point, wherein the level is an indication of the presence or progression of the arthritic disease.

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patent: 4656137 (1987-04-01), Balassa
Dingle et al., 1979, Biochem. J. 184:177-180.
Treadwell et al., 1986, Archives of Biochem. and Biophys. 251:715-723.

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