Cartilage/Bone inducing materials for preparation

Details Cartilage/Bone inducing materials for preparation Cartilage/Bone inducing materials for preparation

2007-07-03

2007-07-03

Weber, Jon (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S021800, C530S333000, C530S354000, C435S069400

Reexamination Certificate

active

10885099

ABSTRACT:
A cartilage and bone morphogenetic repairing composition which contains a bone morphogenetic protein and a polyoxyethylene-polyoxypropylene glycol is disclosed. It is preferable that the molecular weight of a polyoxypropylene, i.e., a component of said polyoxyethylene-polyoxypropylene glycol, is in the range of about 1,500-4,000 and the weight ratio of ethylene oxide is in the range of 40-80%/molecule, and a concentration of said polyoxyethylene-polyoxypropylene glycol in an aqueous solution is about 10-50%. The composition may be applied in a cartilage and bone morphogenetic method without a surgical operation and comprises a bone morphogenetic protein and a carrier which has a high bio-absorption, a good affinity to the bone morphogenetic protein and is capable of temperature dependent gel-sol reversible transition. The composition may conveniently be applied locally to the site of a bone fracture or bone defect.

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