Carriers targettable to organ

Details Carriers targettable to organ Carriers targettable to organ

1997-05-27

2000-11-21

Johnson, Nancy A.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 541, 525 542, 525 5411, 527200, 527207, 530322, 530395, 514 2, 514 8, C08G 6348, C08G 6391, A61K 3814, C07K 100

Patent

active

061504610

ABSTRACT:
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a part capable of binding to the foreign substance electrostatically, and contains one or more monomer unit having side chain with amino or imino group capable of coupling to hyarulonic acid, which is useful for delivering a foreign substance to a target organ, especially liver.

REFERENCES:
patent: 4908404 (1990-03-01), Benedict et al.
patent: 5523222 (1996-06-01), Page et al.
Ferkol, T. et al. Regulation of the Phospholpyruvate Carboxykinase/Human Factor IX Gene Introduced into the Lives . . . FASEB J. vol. 7, 1081, Aug. 1993.
Cera, C. et al. Water-Soluble Polysaccharide-Anthracycline Conjugates: Biological Activity Anti-Cancer Drug Design, vol. 7 143, Nov. 1992.
Mikawa, M. et al. (1996). "Application of Receptor-Directed Glycopolymers for Magnetic Resonance Imaging Contrast Media." Fifth World Biomaterials Congress, May 29-Jun. 2, 1996, Toronto, Canada.

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