Carrier system for specific artery wall gene delivery

Details Carrier system for specific artery wall gene delivery Carrier system for specific artery wall gene delivery

2007-09-04

2007-09-04

Crouch, Deborah (Department: 1632)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S455000, C435S461000

Reexamination Certificate

active

10416381

ABSTRACT:
An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine) (PEG-g-PLL). Methods of making and using the composition for gene transfer are also described.

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Nah, Jae-Woon, et al. Artery Wall binding peptide-poly(ethylene glycol)-grafted-poly(L-lysine)-based gene delivery to artery wall cells. Journal of Controlled Release 78(273-284). 2002.

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