Carrier protein having an adjuvant effect

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

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C530S402000, C530S807000, C424S197110, C424S192100, C424S190100, C424S282100, C424S259100, C424S234100, C424S194100, C435S069700, C435S069300

Reexamination Certificate

active

07408044

ABSTRACT:
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.

REFERENCES:
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patent: WOA92 04375 (1992-03-01), None
patent: WOA93 14207 (1993-07-01), None
patent: WOA 95 27787 (1995-10-01), None
patent: WO 9614415 (1996-05-01), None
Lawrence, J.G. et al., ‘Molecular and evolutionary relationships among enteric bacteria’, J. of General Microbiology, vol. 137 No. 8. pp. 1911-1921.
Haeuw et al. Eur. J. Biochem. 255; 446-454, 1988.
Bizzini et al. Asian Pac. J. Allergy Immunol. 2: 144-153, 1984.
Bizzini et al. Biomed. Pharmacother. 46: 491-494, 1992.

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