Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-05-10
2008-12-02
Haddad, Maher M (Department: 1644)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S009300, C424S009340, C530S391300
Reexamination Certificate
active
07459143
ABSTRACT:
The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.
REFERENCES:
patent: 4758524 (1988-07-01), Bundesen et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5837821 (1998-11-01), Wu
patent: 6056957 (2000-05-01), Chou et al.
patent: 6132719 (2000-10-01), Kohno et al.
patent: 6180370 (2001-01-01), Queen et al.
patent: 6180377 (2001-01-01), Morgan et al.
patent: 6632927 (2003-10-01), Adair et al.
patent: 7087724 (2006-08-01), Carr et al.
patent: 0 239 400 (1987-09-01), None
patent: 0 347 933 (1989-12-01), None
patent: WO 91/02547 (1991-03-01), None
patent: WO 94/09034 (1994-04-01), None
patent: WO 98/52976 (1998-11-01), None
patent: WO 00/34317 (2000-06-01), None
Rudikoff et al. Single amino acid substitution altering antigen-binding specificity. Proc Natl Acad Sci U S A. Mar. 1982; 79(6):1979-83.
Panka et al, Variable region framework differences result in decreased or increased affinity of variant antI-digoxin antibodies. Proc Natl Acad Sci U S A. May 1988;85(9):3080-4.
Lewis Securities Ltd. http://www.comupdate.com.au/issues/dec98.htm, pp. 1-4, Dec. 1998.
Morries et al. Single photon emission computed tomography of pulmonary emboli and venous thrombi using anti-D-dimer. Am J Respir Crit Care Med. May 1, 2004;169(9):987-93.
Adams et al., “Highly Specific In Vivo Tumor Targeting by Monovalent and Divalent Forms of 741F8 Anti-c-erbB-2 Single-Chain FV,” Cancer Research, 53:4026-4034 (1993).
Agen Media Release. “Major Development in Agen/BII Blood Clot Imaging Technology,” Agen Biomedical Limited—Media Release located at http://web.archive.org/web/2001602122513/www.agen.com.au
ews/mr011.htm visited on Sep. 7, 2002 (2 pages).
Altschul et al., “Gapped Blast and PSI-Blast: A New Generation of Protein Database Search Programs,” Nucl. Acids. Res. 25(17):3389-3402 (1997).
Attwood TK. Genomics. The Babel of Bioinformatics. Science, 290(5491):471-473 (2000).
Ausubel et al., “Chapter 15: Polymerase Chain Reaction” In Current Protocols in Molecular Biology, John Wiley & Sons Inc., 3(56):1-2, 15.0.1-15.6.9 (2001).
Bautovich et al., “Detection of Deep Venous Thrombi and Pulmonary Embolus With Technetium-99M-dd-3b6/22 Anti-Fibrin Monoclonal Antibody FAB' Fragment,” J. Nucl. Med. 35(2):195-202 (1994).
Bechtol, “Quantitative Absorption/Blocking Assay,” Monoclonal Antibodies Hybridomas: A New Dimension in Biological Analyses, Plenum Press, New York New York, pp. 383-384 (1981).
Bechtol, “Radioimmunoassay,” Monoclonal Antibodies Hybridomas: A New Dimension in Biological Analyses, Plenum Press, New York New York, pp. 381-382 (1981).
Biovation Therapeutic Antibodies J591 and 3B6 Antibodies. http://www.biovation.co.uk/pages/products/1/. pp. 1(2004).
Bonner et al., “Reduction in the Rate of DNA Reassociation by Sequence Divergence,” J. Mol. Biol., 81(2):123-135 (1973).
Budzynski et al., “Antigenic Markers on Fragment DD, a Unique Plasmic Derivative of Human Crosslinked Fibrin,” Blood, 54(4):794-804 (1979).
Bulens et al., “Construction and Characterization of a Functional Chimeric Murine-Human Antibody Directed Against Human Fibrin Fragment-D Dimer” Eur. J. Biochem. 195:235-242 (1991).
Chothia, et al., “Canonical Structures for the Hypervariable Regions of Immunoglobulins,” J. Mol. Biol., 196:901-917 (1987).
Chothia, et al., “Structural Repertoire of the Human VHSegments,” J. Mol. Biol., 277:799-817 (1992).
Coligan, et a., Current Protocols in Immunology, vol. 1, John Wiley & Sons, Inc., USA, Supplement 54, Table of Contents pp. 1-10 (1991-1997).
Cumber et al., “Comparative Stabilities In Vitro and In Vivo of a Recombinant Mouse Antibody FvCys Fragment and A bisFvCys Conjugate,” J. Immunol., 149(1):120-126.
Daugherty et al., “Polymerase Chain Reaction Facilitates the Cloning, CDR-Grafting, and Rapid Expression of a Murine Monoclonal Antibody Directed Against the CD18 Component of Leukocyte Integrins,” Nucleic Acids Research 19(9):2471-2476 (1991).
Davies et al., “Camelising Human Antibody Fragments: NMR Studies on VH Domains,” FEBS Lett. 339:285-290 (1994).
Devine et al., “Monoclonal Antibody to Fibrin D-Dimer (DD-3B6) Recognizes an Epitope on the γ-Chain of Fragment D” Amer. J. Clin. Pathol., 89(5):663-666 (1988).
Foung et al., “Generation of Human Monoclonal Antibodies by Fusion of EBV-Activated B Cells to a Human-Mouse Hybridoma,” Chapter 13, Methods in Enzymology, vol. 121, Immunochemical Techniques, Part I, Hybridoma Technology and Monoclonal Antibodies, Langone and Vunakis Editors, Academic Press, Inc., New York, pp. 168-174 (1986).
Gefter et al., “A Simple Method for Polyethylene Glycol-Promoted Hybridization of Mouse Myeloma Cells,” Somatic Cell Genet, 3(2):231-236 (1977).
Glockshuber, et al., “A Comparison of Strategies to Stabilize Immunoglobulin FV-Fragments,” Biochem, 29:1362-1367 (1990).
Graeff et al., “Detection and Relevance of Cross-Linked Fibrin Derivatives in Blood,” Seminars in Thrombosis and Hemostatis, 8(1):57-68 (1982)
Hamers-Casterman, et al., “Naturally Occurring Antibodies Devoid of Light Chains,” Nature, 363:446-448 (1993).
Jonak et al., “Peroxidase-Conjugated Antiglobulin Method for Visual Detection of Cell-Surface Antigens,” Monoclonal Antibodies Hybridomas: A New Dimension in Biological Analyses Plenum Press, New York, New York, pp. 378-380 (1981).
Jones, et al., “Replacing the Complementarity-Determining Regions in a Human Antibody With Those From a Mouse,” Nature, 321:522-525.
Kabat et al., Sequences of Proteins of Immunological Interest, U.S. Department of Health and Human Services, 5thedition, NIH Publication No. 91-3242, pp. iii-xi (Table of Contents) (1991).
Kennett, “Enzyme-Linked Antibody Assay Cells Attached to Polyvinyl Chloride Plates,” Monoclonal Antibodies Hybridomas: A New Dimension in Biological Analyses, Plenum Press, New York, pp. 376-377 (1981).
Kohler, “Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity,” Nature 256:495-497 (1975).
Kohler, “Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion,” Eur. J. Immunol., 6(7):511-519 (1976).
Kostelny et al., “Formation of a Bispecific Antibody by the Use of Leucine Zippers,” J. Immunol., 148(5):1547-1553 (1992).
Krebber et al., “Reliable Cloning of Functional Antibody Variable Domains From Hybridomas and Spleen Cell Repertoires Employing a Reengineered Phage Display System,” J. Immunol. Methods, 201(1):35-55 (1997).
Ku, et al. “Alternate Protein Frameworkds for Molecular Recognition,” Proc. Natl. Acad. Sci. USA, 92:6552-6556 (1995).
Lewis Securities Ltd, http://www.comupdate.com.au/issues/dec98.htm, pp. 1-4, Dec. 1998.
Liu et al., “Chimeric Mouse-Human IgG1 Antibody That can Mediate Lysis of Cancer Cells,” Proc. Natl. Acad. Sci. USA, 84:3439-3443 (1987).
Marmur et al., “Determination of the Base Composition of Deoxzyribonucleic Acid From Its Thermal Denaturation Temperature,” J. Mol. Biol., 5:109-118 (1962).
Orlandi et al., “Cloning Immunoglobulin Variable Domains for Expression by the Polymerase Chain Reaction,” Proc. Natl. Acad. Sci. USA, 86:3833-3837 (1989).
Pack et al., “Miniantibodies: Use of Amphipathic Helices to Produce Functional, Flexibly Linked Dimeric FV Fragments With High Avidity inEscherichia Coli,” Biochem., 31(6):1579-1584 (19
Carr Francis J.
Hamilton Anita A.
Agen Biomedical Ltd.
Haddad Maher M
Robins & Pasternak LLP
LandOfFree
Carrier molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carrier molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carrier molecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4023554