Carrier material for use in chromatography or carrying out enzym

Details Carrier material for use in chromatography or carrying out enzym Carrier material for use in chromatography or carrying out enzym

1987-09-09

1989-11-21

Lesmes, George F.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

2101982, 210656, 428402, 428403, 435180, 436531, 521142, 530810, 530815, C12N 1108, G01N 33545, C08F11000, B32B 516

Patent

active

048822264

ABSTRACT:
A carrier material usable as such in chromatographic separations or as a starting material which, upon linkage to it of compounds containing ionic groups, ligands or bio-active materials can be used as ion exchanger, as a clinical selective adsorbent, as a medium in affinity chromatography or in enzymatic reactions and consists of a core material obtained by addition polymerization of monomers of which at least 50 mole % consists of (meth)acrylic acid or an ester forming equivalent thereof and a hydrophilic coating material, which is covalently bonded to the core by complete or partial conversion of the carboxyl function with a compound containing at least three carbon atoms and an epoxy group, the epoxy groups that are still present having been converted by etherification and/or hydrolysis to form an ester of a compound containing a hydroxyl group or an oligomer thereof having a molecular weight not higher than 1000, as well as a process for preparing the same.

REFERENCES:
patent: 4143203 (1979-04-01), Rigopulos et al.
patent: 4281233 (1981-07-01), Coupek et al.
patent: 4352884 (1982-10-01), Nakashima et al.
patent: 4415700 (1983-11-01), Batz et al.
patent: 4418152 (1983-11-01), Hosaka et al.
patent: 4650769 (1987-03-01), Kakimi et al.
patent: 4663163 (1987-05-01), Hou et al.
patent: 4724207 (1988-02-01), Hou et al.
Turkova, "Affinity Chromatography", Journal of Chromatography Library-vol. 12, 1978, pp. 1-2.
Gribnau, et al, "Affinity Chromatography", Les Colloques de l'Inserm, Ed., 1979, p. 175.

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