Carrier-free radiolabelled metyrapones

Details Carrier-free radiolabelled metyrapones Carrier-free radiolabelled metyrapones

1982-04-12

1984-12-25

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

A61K 4902

Patent

active

044903502

ABSTRACT:
Disclosed is the radiohalolabelling of metyrapone (1-propanone-1,2-di-(3-pyridinyl)-2-methyl), an 11Beta-hydroxylase inhibitor and of related compounds to form imaging agents for the adrenal cortex. Metyrapone was selectively converted to its mono-N-oxide. 4'-Bromo-metyrapone was obtained therefrom by a three-step conversion. Exchange labelling of the latter gave radiolabelled metyrapone. Found suitable as imaging agents are .sup.77 Br-4-bromo-metyrapone; .sup.131 l-4-iodo-metyrapone; .sup.123 l-4-iodometyrapone and their corresponding metyrapoles. Mixtures of these also can be used as imaging agents.

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