Carrier for affinity chromatography immobilized with antibodies

Details Carrier for affinity chromatography immobilized with antibodies Carrier for affinity chromatography immobilized with antibodies

1992-01-31

1992-09-15

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502403, 530413, B01D 1508

Patent

active

051475375

ABSTRACT:
The present invention relates to a carrier for affinity chromatography comprising an insoluble carrier and antibodies which are modified by activated polyethyleneglycol and immobilized on the insoluble carrier, the antibodies being modified by activated polyethylene glycol at a location other than at an immobilizing site.

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patent: 4814098 (1989-03-01), Inada
Hackh's Chemical Dictionary, Fourth Edition, McGraw Hill New York, 1972, pp. 192-193.
Abuchowski et al, "Effect of Covalent Attachment of Polyethylene Glycol on Immunogencity and Circulating Life of Bovine Liver Catalase", The Journal of Biological Chemistry, 252, No. 11, pp. 3582-3586 (1977).
Abstracts of Japanese Biochemistry Symposium of the Japanese Biochemical Society, 1986, 58, No. 8 (1986).
Sada et al, "Effects of Coupling Method and Ligand Concentration on Adsorption Equilibrium in Immuno-Affinity Chromatography", Journal of Chemical Engineering of Japan, 1900, No. 6, pp. 502-506 (1986).
Experiment and Application of Affinity Chromatography, published by Kodansha, pp. 32, 33, 64-67, 70-75 (1976).

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