Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1982-06-25
1984-10-23
Padgett, Benjamin R.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436524, 436527, 436532, 435 7, G01N 3354, G01N 3356
Patent
active
044789467
ABSTRACT:
The invention provides an immuno-reactant, being either an antigen or an antibody covalently bonded to a cross-linked film, more particularly composed of cross-linked protein or peptides, enveloping a carrier body, e.g. a solid, non-porous glass bead of 6 mm diameter. The immuno-logically active parts of the immuno-reactant are present on the surface in a form in which they are available for immunosorption. If the immuno-reactant is a protein, e.g. an antibody, it can provide all or part of the film-forming material. In a particular embodiment the film carries antibodies against a second type of antibody which is captured immunosorptively to form a "double layer" carrier-bound immunosorbent, the antigen capturing sites of the second type of antibody providing the immunosorption sites of the product. The immunosorbents are used, for example, for RIA or ELISA assays.
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Polson Alfred
Van der Merwe Kirsten J.
Moskowitz M.
Padgett Benjamin R.
South African Inventions Development Corporation
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