Carrier base material for prolonged release therapeutic composit

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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106169, 106171, 106197R, 106197C, 536 85, 536 87, A61K 4700, C08B 1120, C08B 11193, C08L 126

Patent

active

043574696

ABSTRACT:
A carrier base material adapted to be combined with a therapeutically active medicament and shaped and compressed to form a sustained release therapeutic composition having a long-lasting, slow and regular incremental release of the medicament upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and either up to 30% ethylcellulose or 30% sodium carboxymethylcellulose or both, and wherein the carrier base material has been subjected to hydrolysis and oxidation successively or concurrently until the carbonyl content ranges from 0.2-3.0 grams/100 grams, the carboxyl content ranges from 0.60-2.60 grams/100 grams and the moisture content is in the range of 0.5-3.9%.

REFERENCES:
patent: 3590117 (1971-06-01), Christenson et al.
patent: 3594467 (1971-07-01), Christenson et al.
patent: 3870790 (1975-03-01), Lowey et al.
patent: 4226849 (1980-10-01), Schor

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