Carnosic acid obtention and uses

Details Carnosic acid obtention and uses Carnosic acid obtention and uses

1991-09-18

1993-10-26

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514934, A61K 3105

Patent

active

052567001

ABSTRACT:
Carnosic acid is obtained by extracting sage and rosemary with an apolar solvent, contacting the extract with an adsorbent material to separate carnosic acid from apolar compounds of the extract, desorbing the adsorbent with a polar solvent and then evaporating the solvent to obtain a residue containing carnosic acid. The carnosic acid contained in the residue may be purified by crystallizing it from the residue.

REFERENCES:
patent: 4450097 (1984-05-01), Nakatani et al.
patent: 4638095 (1987-01-01), Chang et al.
patent: 5102659 (1992-04-01), Hudson
Linde, "Ein neues Diterpen aus Salvia officinalis L. und eine Notiz zur Konstitution von Pikrosalvin", Helv. Chim. Acta. 47, No. 136, 1234 (1964) [p. 1, 1. 21].
Wenkert, et al., "Chemical Artifacts from the Family Labiatae", J. Org. Chem. 30, 2931 (1965) [p. 1, 1. 22].
Savona, et al., "Terpenoids of Cultivated Salvia Canariensis", J. Nat. Prod. 46, No. 2, 593 (1983) [p. 1, 1. 24].
de La Torre, et al., "Terpenoids From Salvia Willeana and S. Virgata", Phytochemistry 29, 668 (1990) [p. 1, 1. 25].
Brieskorn, et al., "Carnosolsaure, der wichtige antioxydativ wirksame Inhaltsstoff des Rosmarin- und Salbeiblattes", Z. Lebensm. Unters. Forsch. 141, 10 (1969) [p. 1, 1. 28].
Chemical Abstracts-Carnosic Acid and Derivatives: (a) 86, 117603r, (1976); (b) 90, 49011b, (1978); (c) 97, 67513r, (1981); (d) 97, 69163a, (1981); (e) 97, 69164b, (1981); (f) 104, 221930w, (1986); (g) 111, 130594t (1989); (h) 97, 84835q (1982) [p. 1, 1s. 32-35].
Public Database Abstract Japanese Patent Application 59 103 665 [p.2, 1. 2].
Brieskorn, et al., "Die Struktur des Pikrosalvins, eines Diterpen-o-diphenol-lactons aus dem Salbeiblatt", Chem. Ber. 95, 3034 (1962) [p. 2, 1. 12].
Brieskorn, et al., "The Structure of Carnosol", J. Org. Chem. 29, 2293 (1964) [p.2, 1. 13].
Inatani, et al., "Structure of a New Antioxidative Phenolic Diterpene Isolated from Rosemary (Rosmarinus officinalis L.).", Agric. Biol. Chem. 46(6) 1661 (1982) [p. 2, 1. 14].
Houlihan, et al., "Elucidation of the Chemical Structure of a Novel Antioxidant, Rosmaridiphenol, Isolated from Rosemary", J. Am. Oil Chem. Soc. 61, 1036 (1984) [p. 2, 1. 15].
Meyer, et al., "Diterpenoid Total Synthesis, An A.fwdarw.B.fwdarw.C Approach. III. Total Synthesis of Ethyl dl-Carnosate Dimethyl Ether", Tetrahedron Letters, No. 36, pp. 4261 (1966) [p. 3, 1. 19].
Shew, et al., "Diterpenoid Total Synthesis, An A.fwdarw.B.fwdarw.C Approach V. Total Synthesis of dl-Carnosol Dimethyl Ether and dl-Carnosic Acid Dimethyl Ether", Tetrahedron Letters, No. 25, p. 2963 (1968) [p. 3, 1. 20].
Meyer, et al., "Diterpenoid Total Synthesis, an A.fwdarw.B.fwdarw.C Approach. VIII. Introduction of Oxygen at Carbon-11. Total Synthesis of (.+-.)-Cernosic Acid Dimethyl Ether.sup.1 and (.+-.)-Carnosol Dimethyl Ether.sup.1 ", J. Org. Chem., vol. 41, No. 6, (1976) [p. 3, 1. 20].
Brieskorn, et al., "Naturliche und synthetische Derivate der Carnosolsaure.", Arch. Pharm. 302, 641 (1969) [p.3, 1.29].
European Search Report.
Chemical Abstracts: 88, 69046d, (1978).
Dentali, et al., "16-Hydroxycarnosic Acid, A Diterpene From Salvia Apiana", Phytochem., vol. 29, No. 3, 993, (1990).

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