Carnitine directed pharmaceutical agents

Details Carnitine directed pharmaceutical agents Carnitine directed pharmaceutical agents

1989-05-04

1991-04-16

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

260403, 424450, 4284022, 514 2, 514 17, 514305, 514547, 514556, 514821, 530330, 530812, A61K 3124, A61K 3144, A61K 3702, C07K 1702

Patent

active

050082884

ABSTRACT:
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug for combating arrythmia, etc. The linkage is chemical through one or more alcohol, carboxyl or amine groups using reagents such as glutaraldehyde, dicarboxylic acid anhydrides and acid halides and carbodiimides. Carnitine derivatives are also incorporated into liposomes which are then used as carriers of active pharmaceutical agents.

REFERENCES:
patent: 3929756 (1975-12-01), Leeman et al.
patent: 3998790 (1976-12-01), Branstrom et al.
patent: 4320110 (1982-03-01), DeFelice
patent: 4327725 (1982-05-01), Cortese et al.
patent: 4401827 (1983-08-01), DeWitt
patent: 4440740 (1984-04-01), Fix et al.
patent: 4443475 (1984-04-01), Cavazza
patent: 4537772 (1985-08-01), Alexander et al.
patent: 4742081 (1988-05-01), Stracher et al.
patent: 4866040 (1989-09-01), Stracher et al.

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