Carnitine conjugates of adamantanamines and neramexane...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C514S626000, C514S511000

Reexamination Certificate

active

07977511

ABSTRACT:
This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory diseases such as rheumatoid arthritis, and cerebral ischemia, hyperlipidemia, and diabetes.

REFERENCES:
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patent: 2005/0049312 (2005-03-01), Makovec et al.
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C.G. Parsons et al., “Memantine is a Clinically Well Tolerated NMDA Receptor Antagonist—a Review of Preclinical Data”, Neutopharmacology 38, 735-767 (1999), Pergamon.
Gordon K. Wilcock, “Memantine for the Treatment of Dementia”, The Lancet, Neurology 2, 503-505 (Aug. 2003).
A. Bianchetti et al., “Effects of Acetyl-L-carnitine in Alzheimer's disease patients unresponsive to AChE-l”, Curr. Med. Res. and Opinion 19(4), 350-353 (2003), Librapharm Ltd.
A. Spagnoli, MD et al., “Long-term Acetyl-L-carnitine Treatment in Alzheimer's Disease”, Neurology 41, 1726-1732 (1991).
J. David Leander et al., “N-Methyl-D-aspartic acid-induced lethality in mice:selective antagonism by phencyclidine-like drugs”, Brain Res. 448, 115-120 (1988), Elsevier Sci.
C.G. Parsons et al., Neuropharmacology 34(10),1239-1256 (1995), Elsevier Sci.

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