Cark protein and nucleic acid molecules and uses therefor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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C435S194000, C435S252300, C435S320100, C435S325000, C530S350000

Reexamination Certificate

active

06987000

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated CARK nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CARK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CARK gene has been introduced or disrupted. The invention still further provides isolated CARK proteins, fusion proteins, antigenic peptides and anti-CARK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 194006 (1992-04-01), None
patent: 00/73469 (2000-12-01), None
Baumeister, A. et al. “Accumulation of muscle Ankyrin repeat protein transcript reveals local activation of primary myotube end compartments during muscle morphogenesis,”J. Cell. Biol.,139(5): 1231-1242 (1997).
Bevan, M. et al. “Analysis of 1.9 Mb of contiguous sequence from chromosome 4 ofArabidopsis thaliana,” Nature,391 (6666):485-488 (1998).
Cairns, B.R. et al., “Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase,”Genes Dev.,6(7):1305-1318 (1992).
Cannon, J.F. et al. “Characterization ofSaccharomyces cerevisiaegenes encoding subunits of cyclic AMP-dependent protein kinase,”Mol. Cell. Biol.,7 (8):2653-2663 (1987).
Costigan, C. et al. “A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth,”Mol. Cell. Biol.,12 (3):1162-1178 (1992).
Delcommenne, M. et al., “Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase,”PNAS USA,95:11211-11216 (1998).
Eber, S.W. et al. “Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis,”Nat. Genet.,13 (2):214-218 (1996).
Ebina, Y. et al. “The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling,”Cell,40 (4): 747-758 (1985).
Fearon, K. et al. “Structure and function of MRP20 and MRP49, the nuclear genes for two proteins of the 54 S subunit of the yeast mitochondrial ribosome,”J. Biol. Chem.,267 (8): 5162-5170 (1992).
Feng, X.-H., et al. “Cloning and characterization of a novel member of protein kinase family from soybean,”Biochim. Biophys. Acta.,1172:200-204 (1993).
Gallagher, P.G. et al. “An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene,”J. Biol. Chem.,273(3):1339-1348 (1998).
Goto, K. et al. “A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus,”PNAS USA,93: 11196-11201 (1996).
Hsu, S-C. et al. “Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin,”Mol. Cell. Biol.,18(8): 4807-4818 (1998).
Hubbard, S.R. et al. “Crystal structure of the tyrosine kinase domain of the human insulin receptor,”Nature,372 (6508): 746-753 (1994).
Hwang, D.M. et al. “Analysis of expressed sequence tags from a fetal human heart cDNA library,”Genomics,30 (2): 293-298 (1995).
Irie,K., et al. “A new protein kinase, SSP31, modulating the SMP3 gene-product involved in plasmid maintenance inSaccharomyces cerevisiae,” Gene,108 (1): 139-144 (1991).
Jeyaseelan, R. et al., “A novel cardiac-restricted target for doxorubicin; Carp, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes,”J Biol Chem,272(36):22800-8 (1997).
Johnston, M. et al. “Complete nucleotide sequence ofSaccharomyces cerevisiaechromosome VIII,”Science,265 (5181): 2077-2082 (1994).
Katoh, M., et al. “Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain,”Oncogene,10 (7): 1447-1451 (1995).
Laidlaw, S.M., et al. “Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein,”J. Virol.,72 (8): 6742-6751 (1998).
Lambert, S. et al. “cDNA sequence for human erythrocyte ankyrin,”Proc. Natl. Acad. Sci. U.S.A.,87 (5): 1730-1734 (1990).
Lee, K.S. et al. “Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for aSaccharomyces cerevisiaeprotein kinase C homolog,”Mol. Cell. Biol.,12 (1): 172-182 (1992).
Lisziewicz, J., et al. “Isolation and nucleotide sequence of aSaccharomyces cerevisiaeprotein kinase gene suppressing the cell cycle start mutation cdc25,”J. Biol. Chem.,262 (6): 2549-2553 (1987).
Lux, S.E. et al. “Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins,”Nature,344 (6261): 36-42 (1990).
Miosga, T, et al. “Sequence and function analysis of a 9.74 kb fragment ofSaccharomyces cerevisiaechromosome X including the BCK1 gene,”Yeast,10 (11): 1481-1488 (1994).
Mohammadi, M. et al. “Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism,”Cell,86 (4): 577-587 (1996).
Novak, A. et al. “Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways,”PNAS USA,95: 4374-4379 (1998).
Otsuka, A.J. et al. “An ankyrin-related gene (unc-44) is necessary for proper axonal guidance inCaenorhabditis elegans,” J. Cell Biol.,129 (4): 1081-1092 (1995).
Otto, E. et al. “Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes,”J. Cell Biol.,114 (2): 241-253 (1991).
Percival-Smith, A. et al. “Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation ofSaccharomyces cerevisiae,” Mol. Cell. Biol.,6 (7):2443-2451 (1986).
Radeva, G. et al. “Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression,”J. Biol. Chem.,272(21): 13937-13944 (1997).
Rhodes, N. et al. “STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast,”Genes Dev.,4 (11): 1862-1874 (1990).
Russo, A.A. et al. “Structural basis of cyclin-dependent kinase activation by phosphorylation,”Nat. Struct. Biol.,3 (8): 696-700 (1996).
Saito, H. et al. “Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence,”J. Biol. Chem.,272(13):8157-8160 (1997).
Sheffield, V.C. et al. “Identification of a complex congenital heart defect susceptibility locus by using DNA pooling and shared segment analysis,” Human Molecular Genetics, 6(1): 117-121 (1997).
Sivasubramanian, N. et al., Cardiac myotrophin exhibits rel/NF-kB interacting activity in vitro,J. Biol. Chem.,271(5): 2812-2816 (1996).
Somers, S.S. et al. “Comparison of transforming growth factor beta and a human tumour-derived suppressor factor,”Cancer Immunology Immunotherapy,33:217-22 (1991).
Tan, J.L. et al. “Developmentally regulated protein-tyrosine kinase genes inDictyostelium discoideum,” Mol. Cell. Biol.,10: 3578-3583 (1990).
Tanaka, T. et al. “Construction of a Normalized Directionally Cloned cDNA Library from Adult Heart and Analysis of 3040 Clones by Partial Sequencing,”Genomics,35: 231-235 (1996).
Tse, W.T. et al. “Isolation and chromosomal localization of a novel nonerythroid ankyrin gene,”Genomics,10 (4): 858-866 (1991).
Toda, T. et al. “Three different genes inS. cerevisiaeencode the catalytic subunits of the cAMP-dependent protein kinase,”Cell,50: 277-287 (1987).
Jeffrey, P.D. et al. “Mechanism of CDK activation reveal

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