Surgery – Diagnostic testing – Physical characteristics of blood
Patent
1996-12-30
1998-07-21
Bahr, Jennifer
Surgery
Diagnostic testing
Physical characteristics of blood
A61B 500
Patent
active
057827591
ABSTRACT:
The present invention relates to a method and device for creating and testing arterial and venous thrombotic conditions. The invention includes a tube which is inserted into a blood vessel of an animal. The tube contains one or more strands upon which various materials, such as procoagulants and anticoagulants may be placed. Blood flows through the tube and clots form on the threads. After the completion of the test, the tube is removed from the animal, the strands are removed from the tube and the clots may be measured and weighed. In a preferred embodiment, a flowmeter may be connected to the blood vessel to measure the blood flow so that the clot measurements may be correlated with the blood flow.
REFERENCES:
Peters et al., "The Characterisation of Thrombus Development in an Improved Model of Arterio-Venous Shunt Thrombosis in the Rat . . . ", Thrombosis and Haemostasis, vol. 65, pp. 268-274, Mar. 1991.
Inhibition of Platelet-Dependent Thrombosis by Local Delivery of Heparin With a Hydrogel-Coated Balloon; G. L. Nunes, M.D., et al., Circulation, vol. 92, No. 7, Oct. 1, 1995, pp. 1697-1700.
Antithrombotic Effects of Orally Active Synthetic Antagonist of Activated Factor X in Nonhuman Primates; T. Yokoyama, PhD., et al.; Circulation, vol. 92, No. 3, Aug. 1, 1995, pp. 485-491.
An In Vitro Circulation Model for Thrombosis; Influence of Circulating Plasmas on the Binding of Monoclonal Antibodies to Human Fibrin Clots; F. J. McEvoy, et al., Fibrinoloysis, (1995) pp. 309-315.
Experimental Thrombosis on a Collagen Coated Arterioarterial Shunt in Rats: A Pharmacological Model to Study Antithrombotic Agents Inhibiting Thrombin Formation and Platelet Deposition; M. Freund, et al., Thrombosis and Haemostatis, 69 (5) pp. 515-521 (1993).
A Comparative Study of Prothrombinase and Thrombin Inhibitors in a Novel Rabbit Model of Non-Occlusive Deep Vein Thrombosis; S. Hollenbach, et al.; Thrombosis and Haemostatis; 71 (3) pp. 357-362; (1994).
Platelet Interactions with Dacron Vascular Grafts; S. R. Hanson, et al.; Arteriosclerosis 5:595-603; Nov./Dec. 1985.
Chi Liguo
Gallagher Kim P.
Saganek Lori
Uprichard Andrew
Almer Charles W.
Bahr Jennifer
Warner-Lambert & Company
Winakur Eric F.
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