Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon

Details Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon

1981-03-18

1984-12-04

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544238, 544239, A61K 3150

Patent

active

044864310

ABSTRACT:
4,5-Dihydro-4-R-6-(4-pyridinyl)-3(2H)-pyridazinone (IA) or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl, is shown as the active component in cardiotonic composition and method for increasing cardiac contractility in a patient requiring such treatment. Also shown is the preparation of IA by reacting a lower-alkyl 2-R-4-(BN)-4-cyano-4-(4-pyridinyl)butanoate with hydrazine, where R is hydrogen or methyl, and BN is 4-morpholinyl, 1-piperidinyl or 1-pyrrolidinyl.

REFERENCES:
patent: 4298609 (1981-11-01), Lesher et al.
patent: 4304776 (1981-12-01), Lesher et al.
patent: 4304777 (1981-12-01), Lesher et al.
patent: 4337253 (1982-06-01), Lesher et al.
patent: 4346221 (1982-08-01), Lesher et al.
patent: 4404203 (1983-09-01), Sircar
McEvoy and Allen, [J. Org. Chem. 38, 4044-4048 (1978); J. Med. Chem. 17, 281-286 (1974)].
Curran and Ross, [J. Med. Chem. 17, 273-281 (1974)].
Albright, McEvoy and Moran, [J. Heterocyclic Chem. 15, 881-892 (1978)].
McEvoy and Albright, [J. Org. Chem. 44, 4597-4603 (1979)].
Leete et al., [J. Org. Chem. 37, 4465-4466 (1972)].

Affiliated with

Also associated with

Rating

Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1582070