Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1981-11-04
1983-11-29
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548321, A61K 31415
Patent
active
044180713
ABSTRACT:
The use of novel imidazolecarboxylic acid derivatives of the following general structure which are useful as antihypertensives, cardiotonics and antithrombotics ##STR1## wherein Q and T are an oxygen or sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydrogen or --CH(R.sub.3)R.sub.4 ; R2 is lower alkoxy, phenoxy or phenoxy substituted at the ortho, meta, or para position with lower alkyl, lower alkoxy, hydroxy, halogen, trifluoromethyl, lower alkylthio, lower alkylsulfone, or lower alkylsulfoxide; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, hydroxy, lower alkoxy, lower alkylcarbonyl, --ONO.sub.2 or halogen; and their pharmaceutically acceptable salts thereof.
REFERENCES:
Chemical Abstracts, 87:152201a (1977) [Miyoshi et al., Japan Kokai No. 77 46,074, 4/12/77].
Chemical Abstracts, 87:5972z (1977) [White, Ger. Offen. No. 2,634,430, 2/10/77].
Dage Richard C.
Grisar J. Martin
Schnettler Richard A.
McDonald Raymond A.
Merrell Dow Pharmaceuticals Inc.
Nesbitt Stephen L.
Schwartz Richard A.
Street Gary D.
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