Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates

Details Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates

1986-07-31

1988-09-06

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514342, 514343, 514346, 514350, 546261, 546281, 546283, 546284, 546276, 546298, 546299, C07D21186, C07D40106, A61K 31455

Patent

active

047693800

ABSTRACT:
Novel 3-carboxy- and 3-carbalkoxy-5-benzoyl-2(1H)-pyridinones as well as the pharmaeutically acceptable salts thereof are cardiotonic agents useful in the treatment of heart failure.

REFERENCES:
patent: 3769291 (1973-10-01), Parker et al.
patent: 4347363 (1982-08-01), Singh
Jaques et al., Chem. Abstracts (9), Abst. No. 56686k, Aug. 6, 1972.
Sunthankar, Chem. Abstracts, vol. 80(23), Abst. No. 133,202r, Jun. 10, 1974.
Crombie et al., Chem. Abstracts, vol. 91(15), Abst. No. 123,613p, Oct. 8, 1979.
Sunthankar, Chem. Abstracts, vol. 93(11), Abst. No. 114,281t, Sep. 15, 1980.
CA, 83:206076b provided. T. Hatada et al., Yakugaku Zasshi, 95(6), 623-28 (1975).
CA, 93:71644u provided. M. Augustin, S. Bielka, Z. Chem., 20(3), 96-7 (1980).
Baker, S. R. et al., J. Chem. Soc., Perkin Trans. 1(3), 677-85 (1979).

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