Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Reexamination Certificate
2007-01-02
2007-01-02
Lankford, Jr., Leon Blaine (Department: 1651)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
C435S232000, C435S233000
Reexamination Certificate
active
10630548
ABSTRACT:
The present invention relates to methods and compositions related to the use of enzymes of the allene oxide synthase family for reducing myocardial ischemia reperfusion injury associated with myocardial infarction, thrombolysis, angioplasty and coronary bypass surgery. The methods of the invention comprise administration of allene oxide synthases, which are capable of eliminating lipid hydroperoxides, as a potent cardioprotective agent. The invention is based on the discovery that administration of allene oxide synthase following severe global ischemia stimulates cardiac recovery.
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Arizona Board of Regents
Lankford, Jr. Leon Blaine
McDonnell Boehnen & Hulbert & Berghoff LLP
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