Cardioglycoside derivatives of the strophanthidin type, a proces

Details Cardioglycoside derivatives of the strophanthidin type, a proces Cardioglycoside derivatives of the strophanthidin type, a proces

1975-06-12

1976-08-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424182, C07J 1900

Patent

active

039753735

ABSTRACT:
Cyclic acetals or ketals of cardioglycosides derived from k-strophanthidin or strophanthidol are more readily absorbed by the stomach and intestine than the parent cardioglycoside. The acetals are produced by reaction of the parent cardioglycoside, e.g., strophanthidindigitoxide, with an aldehyde or ketone, or the corresponding acetal or ketal, in the presence of an acid condensation catalyst, to produce the k-strophanthidin derivative optionally followed by reduction to the strophanthidiol derivative.

REFERENCES:
patent: 3476742 (1969-11-01), Voigtlander et al.
patent: 3781269 (1973-12-01), Haede et al.

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