Cardioactive 12-dehydrodigoxin-oximes

Details Cardioactive 12-dehydrodigoxin-oximes Cardioactive 12-dehydrodigoxin-oximes

1980-05-19

1981-09-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugate includes potentiator; or composition comprising...

536 7, C07J 1700, A61K 3158

Patent

active

042923140

ABSTRACT:
The present invention provides 12-dehydrodigoxin oximes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms, lower acyl radicals or lower alkyl radicals or R.sub.1 and R.sub.2 together can represent an alkylidene radical containing 2 to 6 carbon atoms and R.sub.3 is a hydrogen atom or a lower alkyl or aralkyl radical. The present invention also provides a process for the preparation of these oximes and pharmaceutical compositions containing them and is also concerned with the use of these oximes for the preparation of pharmaceuticals for the treatment of cardiac insufficiency.

REFERENCES:
patent: 3937697 (1976-02-01), Stache et al.
patent: 4021546 (1977-05-01), Bodor
patent: 4166849 (1979-09-01), Cohnen

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