Cardio myopeptidin, the production and the use thereof

Details Cardio myopeptidin, the production and the use thereof Cardio myopeptidin, the production and the use thereof

2004-02-23

2008-09-23

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S350000

Reexamination Certificate

active

07427663

ABSTRACT:
The present invention relates to a cardio myopeptidin which is isolated from the hearts of non-human healthy mammals. The molecular weight of the cardio myopeptidin is less than 10000 Dalton, the peptide content thereof being 75%˜90%, the free amino acid content 6%˜15%, the ribonucleic acid content less than 2%, and the deoxyribonucleic acid content less than 7.5%. The present invention further provides a method of producing the cardio myopeptidin and the use thereof in producing pharmaceuticals for treating cardiac disorders, specifically the use in producing pharmaceuticals for treating myocardial ischemic and reperfusion injury. The cardio myopeptidin of the present invention can work directly on myocytes, promoting the repair of injuries caused by various reasons, and providing a new way to relieve ischemic and reperfusion injury, and to promote the repair of injured myocardium.

REFERENCES:
patent: 1108663 (1995-09-01), None
International Search Report dated Jun. 3, 2004 for PCT Application PCT/CN2004/000138.
Pharmaceutical Biotechnology, 1996, vol. 3(2); 98-100, Zhang Xiujian “Studies on Biochemical Characters and Effect on DNA Synthesis of Myocardial Cells of Heart Active Factor”.

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