Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems
Reexamination Certificate
2005-03-15
2005-03-15
Jastrzab, Jeffrey R. (Department: 3762)
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Electrical therapeutic systems
Reexamination Certificate
active
06868287
ABSTRACT:
The invention provides a method of treating a heart to remodel gap junctions, obtain gap junctional remodeling and/or alteration or effective refractory period comprising contacting linked multiple electrode pairs to an epicardial surface of a heart, and connecting the electrode pairs to a pacemaker to apply periodic electrical signals to the epicardial surface through the electrode pairs, the signals being applied for a sufficient time and having characteristics sufficient to remodel gap junctions, obtain gap junctional remodeling and/or alteration of effective refractory period in the heart. The invention also provides a device comprising a strip of electrode material having mounted thereon linked multiple electrode pairs arranged in two columns.
REFERENCES:
patent: 3937226 (1976-02-01), Funke
patent: 4088140 (1978-05-01), Rockland et al.
patent: 4628937 (1986-12-01), Hess et al.
patent: 4787389 (1988-11-01), Tarjan
patent: 5111811 (1992-05-01), Smits
patent: 5174289 (1992-12-01), Cohen
patent: 5203348 (1993-04-01), Dahl et al.
patent: 5243978 (1993-09-01), Duffin
patent: 5366485 (1994-11-01), Kroll et al.
patent: 5681308 (1997-10-01), Edwards et al.
patent: 5800464 (1998-09-01), Kieval
patent: 5814079 (1998-09-01), Kieval
patent: 5824028 (1998-10-01), Knisley
patent: 5871505 (1999-02-01), Adams et al.
patent: 5873896 (1999-02-01), Ideker
patent: 5947899 (1999-09-01), Winslow et al.
patent: 6152882 (2000-11-01), Prutchi
patent: 6363279 (2002-03-01), Ben-Haim et al.
Katz AM: T wave “Memory”: Possible causal relationship to stress-induced changes in cardiac ion channels? J Cardiovasc Electrophysiol 1992;3:150-159.
Page, E. Cardiac Gap Junctions. In:The Heart and Cardiovascular System. H.A. Fozzard, E. Haber, R.B. Jennings, A.M. Katz, and H.E. Morgan (eds) . New York: Raven Press Ltd. 1992; 1003-1048. (Exhibit 2).
Spach MS, Miller WT III, Dolber PC, Kootsey JM, Sommer JR, Mosher CE Jr. The functional role of structural complexities in the propagation of depolarization in the atrium of the dog. Cardiac conduction distrubances due to discontinuities of effective axial resistivity.Circ Res. 1982; 50:175-191. (Exhibit 3).
Smith JH, Green CR, Peters NS, Rothery S, Severs NJ. Altered patterns of gap junctions distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy.Am J Pathol. 1991; 139:801-821. (Exhibit 4).
Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones.J Clin Invest. 1991;87:1594-1602. (Exhibit 5).
Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischaemic human hearts.Circulation. 1993;88:864-875. (Exhibit 6).
Campos De Carvalho AC, Tanowitz HB, Wittner M. Dermietzel R, Roy C, Hertzberg EL, Spray DC. Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi.Circ Res. 1992;70:733-742. (Exhibit 7).
Bastide B, Neyses L, Ganten D, Paul M, Willecke K, Traub O. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions.Circ Res. 1993;73:1138-1149. (Exhibit 8).
Fast VG, Darrow BJ, Saffitz JE, Kleber AG. Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities.Circ Res. 1996;79:115-127. (Exhibit 9).
Guerrero-P-A; Schuessler-R-B; Davis-L-M; Beyer-E-C; Johnson-C-M; Yamada-K-A; Saffits-J-E: Slow ventricular conduction in mice heterozygous fora connexin43 null mutation. Journal of Clinical Investigation 1997;99(8): 1991-1998 (Exhibit 10).
Peters NS, Severs NJ, Coromilas J, Wit AL. Disturbed connexin43 gap junctional distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia.Circulation. 1997 95;988-996 (Exhibit 11).
Wijffels MCEF, Kirchhof CJHJ, Dorland R, Allessie MA: Atrial fibrillation begets atrial fibrillation. Circulation 1995;92: 1954-1968. (Exhibit 12).
Kajstura-J; Zhang-X; Liu-Y; Szoke-E; Cheng-W; Olivetti-G; Hintze-T-H; Anversa-P: The cellular basis of pacing-induced dilated cardiomyopathy: Myocyte cell loss and myocyte cellular reactive hypertrophy. Circulation 1995; 92(8) : 2306-2317 (Exhibit 13).
Rosenbaum MB, Blanco HH, Elizari MV, Lazzari JO, Davidenko JM: Electronic modulation of the T wave and cardia memory. Am J Cartel 1982;50:2130222. (Exhibit 14).
Chatteree K, Harris A, Davies G, Leatham A: Electrocardiographic changes subsequent to artificial ventricular depolarization. Br Heart J 1969;31:770-779 (Exhibit 15).
Shvilkin A, Danilo P, Jr. Wang J, Burkhoff D, Anyukhovsky EP, Sosunov EA, Hara M. Rosen MR. The evolution and resolution of long-term cardiac memory. Circulation 1998;97:1810-1817. (Exhibit 16).
del Balzo U, Rosen MR: T wave changes persisting after ventricular pacing in canine heart are altered by 4-aminopyridine but not by lidocaine. Circulation 1992;85: 1464-1472. (Exhibit 17).
Tan, RC; Joyner, RW: Electronic influences on action potentials from isolated ventricular cells. Circ Res: 1990:67: 1071-1081) (Exhibit 18).
Yu H, McKinnon D, Dixon JE, Gao J, Wymore R, Cohen IS, Danilo, P Jr., Shvilkin A, Anyukhovsky EP, Sosunov EA, Hara M, Rosen MR: The transient outward current, Itol, is altered in cardiac memory. Circulation, 1999; 88:1898-1905. (Exhibit 19).
Anyukhovsky EP, Sosunov EA, Feinmark SJ, et al: Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: II. In vivo study. Circulation 1997;96:4019-4026. (Exhibit 20).
Anyukhovsky EP. Sosunov EA, Gainullin RZ, Rosen MR. The controversial M cell J Cardiovasc Electrophysiol,in press. (Exhibit 21).
Yeh-H-I; Dupont-E; Coppen-S; Rothery-S; Severs-N-J: Gap junction localization and connexin expression in cytochemically identified endothelial cells of arterial tissue. Journal of Histochemistry and Cytochemistry 1997; 45(4) : 539-550 (Exhibit 22).
Hoyt RH, Cohen ML, Saffitz JE. Distribution and three-dimensional structure of intercellular junctions in canine myocardium. Circ. Res. 1989;64:563-574. (Exhibit 23).
Peters NS, Wit AL. Myocardial architecture and ventricular arrhythmogenesis. Circulation 1997;97: 1746-1754. (Exhibit 24).
Spach MS, Dolber PC. The relation between discontinuous propagation in anisotropic cardiac muscle and the “vulnerable period” of reentry. In:Cardiac Electrophysiology and ArrhythmiasD.P. Zipes and J. Jalife (eds). Grune and Stratton, Orlando. 1985;241-252. (Exhibit 25).
Wit AL, Janse MJ: Basic mechanisms of arrhythmias, inThe Ventricular Arryhythmisa of Ischemia and Infarction. New York, Futura, 1992, pp. 1-160. (Exhibit 26).
Lesh MD, Pring M, Spear JF: Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. Circ. Res. 1989;65:1426-1440. (Exhibit 27).
Elvan A. Wylie K, Zipes DP: Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling. Circulation 1996;94:2953-60. (Exhibit 28).
Yue-L; Feng-J; Gaspo-R; Li-G-R; Wang-Z; Nattel-S: Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circulation Research 1997;81(4) : 512-525. (Exhibit 29).
Quan W, Rudy Y: unidirectional block and reentry of cardiac excitation: a model study. Circ. Res. 1990;66:367-382. (Exhibit 30).
Van-Der-Velden-Huub-M-W; Van-Kempen-Marjan-J-A; Wijffels-Maurits-C-E-F; Van-Zijverden-Maaike; Groenewegen-W-Antoinette; Allessie-Maurits-A; Jongsma-Habo-J: Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat. Journal-of-Cardiovascular-Electrophysiology. Jun., 1998;9(6) 595-607. (Exhibit 31).
Patel P, Jones DG, Hadjinicolou L, Glenville B, Stanbridge R, Severs NJ, Peters NS. Changes in human atrial connexin expression in atrial fibrillation and ischemic heart disease. Circulation 1997;96(8) :I-17. (Exhibit 32).
Palti Yoram
Peters Nicholas S.
Rosen Michael R.
Cooper & Dunham LLP
Jastrzab Jeffrey R.
Oropeza Frances P.
The Trustees of Columbia University in the City of New York
White John P.
LandOfFree
Cardiac remodeling does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cardiac remodeling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cardiac remodeling will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3370563