Cardiac hypertrophy factor and uses therefor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530380, 424569, 424570, C07K 100, A61K 3514, A61K 3530

Patent

active

055346154

ABSTRACT:
Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

REFERENCES:
patent: 4339441 (1982-07-01), Kalman et al.
patent: 4900811 (1990-02-01), Sutcliffe
patent: 4923696 (1990-05-01), Appel et al.
patent: 5107375 (1991-05-01), Appel et al.
patent: 5166317 (1992-11-01), Wallace et al.
patent: 5202428 (1993-04-01), Schubert
patent: 5206007 (1993-04-01), Ooshima et al.
patent: 5210026 (1993-05-01), Kovesdi et al.
patent: 5214031 (1993-05-01), Uchida
patent: 5215969 (1993-06-01), Springer et al.
patent: 5218094 (1993-06-01), della Valle
patent: 5242798 (1993-09-01), Sutcliffe
patent: 5250414 (1993-10-01), Schwab et al.
patent: 5284932 (1994-02-01), Sen
Chien, "Molecular Advances in Cardiovascular Biology" Science 260:916-917 (May 14, 1993).
Jones et al., "Association Between Inhibition of Arachidonic Adic Release and Prevention of Calcium Loading During ATP Depletion in Cultured Rat Cardiac Myocytes" American Journal of Pathology 135(3):541-556 (1989).
Miller-Hance et al., "In Vitro Chamber Specification During Embroyonic Stem Cell Cardiogenesis" The Journal of Biological Chemistry 268(33):25244-25252 (Nov. 25, 1993).
Pennica et al., "Expression Cloning of Cardiotrophin 1, a Cytokine That Induces Cardiac Myocyte Hypertrophy" Proceedings of the National Academy of Sciences, USA 92:1142-1146 (Feb. 1995).
Bazan, "Neuropoietic Cytokines in the Hematopoietic Fold", Neuron, 7:197-208, (1991).
Boheler et al., "Gene Expression in Cardiac Hypertrophy", TCM, 2(5):176-182, (1992).
Chen et al., "Pharmacological Characterization of the Activity of Endogenous Inotropic Factor from Porcine Left Ventricle", J. Cardiovas. Pharmacol., 22(Suppl. 2):S93-S95, (1993).
Chien et al., "Transcriptional Regulation During Cardiac Growth and Development", Annu. Rev. Physiol., 55:77-95, (1993).
Chien et al., "Regulation of Cardiac Gene Expression During Myocardial Growth and Hypertrophy: Molecular Studies of an Adaptive Physiologic Response", The FASEB J., 5:3037-3046, (1991).
Davis et al., "The Molecular Biology of the CNTF Receptor", Curr. Opin. Cell Biol., 5:281-285, (1993).
Frelin, "Serum Growth Factors for Rat Cardiac Non-Muscle Cells in Culture", J. Molec. and Cell. Cardiol., 12:1329-1340, (1980).
Grimm et al., "Ventricular Nucleic Acid and Protein Levels with Myocardial Growth and Hypertrophy",Cir., Res., XIX:552-558, (1966).
Iwaki et al., ".alpha.-and .beta.-Adrenergic Stimulation Induces Distinct Patterns of Immediate Early Gene Expression in Neonatal Rat Myocardial Cells", J. Biol. Chem., 265(23):13809.varies.13817 (1990).
Kanda et al., "An Interleukin-6 Secreting Myxoma in a Hypertrophic Left Ventricle", Chest, 105(3):962-963, (1994).
Karasik et al., "Growth Factors Identified in Myocardium of Patients with Hypertrophic Cardiomyopathy", Abstract, JACC, 13(2):118A, (1989).
Kishimoto et al., "Cytokine Signal Transduction", Cell, 76:253-262, (1994).
Kitamura et al., "Multimeric Cytokine Receptors", TEM, 5(1):8-14, (1994).
Knowlton et al., "The .alpha..sub.1a -Adrenergic Receptor Subtype Mediates Biochemical, Molecular, and Morphologic Features of Cultured Myocardial Cell Hypertrophy", J. Biol. Chem., 268(21):15374-15380, (1993).
Knowlton et al., "Co-Regulation of the Atrial Natriuretic Factor and Cardiac Myosin Light Chain-2 Genes During .alpha.-Adrenergic Stimulation of Neonatal Rat Ventricular Cells", J. Biol. Chem., 266(12):7759-7768, (1991).
Lee et al., "Atrial Natriuretic Factor Gene Expression in Ventricles of Rats with Spontaneous Biventricular Hypertrophy", J. Clin. Invest., 81:431-434, (1988).
Lee et al., ".alpha..sub.1 -Adrenergic Stimulation of Cardiac Gene Transcription in Neonatal Rat Myocardial Cells", J. Biol. Chem., 263(15):7352-7358, (1988).
Libby, "Long-Term Culture of Contractile Mammalian Heart Cells in a Defined Serum-Free Medium that Limits Non-Muscle Cell Proliferation", J. Mol. Cell Cardiol., 16:803-811, (1984).
Long, "TGF .beta. Isoform Expression and Effect in Neonatal Rat Cardiac Myocytes and Non-myocytes in Culture", Circulation, Abstracts from the 65th Scientific Sessions, 86:I-837, (1992) (abstract 3332).
Long et al., "Trophic Factors in Cardiac Myoctyes", J. Hyper., 8(Suppl. 7):S219-S224, (1990).
Long et al., ".beta.-Adrenergic Stimulation of Cardiac Non-myocytes Augments the Growth-promoting Activity of Non-myocyte Conditioned Medium", J. Mol. Cell. Cardiol., 25:915-925, (1993).
Long et al., "A Growth Factor for Cardiac Myocytes is Produced by Cardiac Nonmyocytes", Cell Reg., 2:1081-1095, (1991).
McDonald et al., "Expression and Characterization of Recombinant Human Ciliary Neuroptrophic Factor from Escherichia coli", Biochimica et Biophysica Acta, 1090:70-80, (1991).
Mir et al., "Isolation of a Negative Inotropic Factor from Blast Cells of Patients with leukaemic Cardiomyophaty", Circulation, 55 & 56(Supp III):III-86, (1977) (abstract 324).
Mir, "Evidence for Non-Infiltrative Neoplastic Cardiomyopaty and Presence of Negative Inotropic Factor in Acute Myeloid Leukaemia: A Clinico-Experimental Study", British Heart J., 39(3):355, (1977).
Mukherjee et al., "Myotrophin Induces Early Response Genes and Enhances Cardiac Gene Expression", Hypertension, 21(2):142-148, (1993).
Mukherjee et al., "Effect of Myotrophin on Induction of Proto-Oncogenes, ANF and Contractile Element Transcript Levels", Circulation(Suppl. I)., 86(4):I-626, (1992) (abstract 2490).
Neben et al., "The Biology of Interleukin 11", Stem Cells, 11(Suppl. 2):156-162, (1993).
Patterson, "The Emerging Neuropoietic Cytokine Family: First CDF/LF, CNTF and IL-6; next ONC, MGF, GCSF?", Curr. Opin. Neurobiol., 2:94-97, (1992).
Ramaciotti et al., "Cardiac Endothelial Cells Modulate Contractility of Rat Heart in Response to Oxygen Tension and Coronary Flow", Circ. Res., 72(5):1044-1064, (1993).
Robbins et al., "Mouse Embryonic Stem Cells Express the Cardiac Myosin Heavy Chain Genes During Development in Vitro", J. Biol. Chem., 265(20):11905-11909, (1990).
Rockman et al., "Segregation of Atrial-Specific and Inducible Expression of an Atrial Natriuretic Factor Transgene in an in vivo Murine Model of Cardiac Hypertrophy", Proc. Natl. Acad. Sci. USA., 88:8277-8281, (1991).
Sadoshima et al., "Autocrine Release of Angiotensin II Mediates Stretch-Induced Hypertrophy of Cardiac Myocytes in Vitro", Cell, 75:977-984, (1993).
Sarzani et al., "Regulation of Cardiac Growth Factors and Growth Factor Receptors Gene Expression by Growth Hormone", Eur. Heart J., 13(ABST. SUPPL):326, (1992).
Sen et al., "Myotrophin: Purification of a Novel Peptide from Spontaneously Hypertensive Rat Heart That Influences Myocardial Growth", J. Biol. Chem., 265(27):16635-16643, (1990).
Sen et al., "Basic Science/Circulation: Myocardial Structure and Pathology-Hypertrophy", Circulation (Suppl. II), 80(4):II-616, (1989) (abstract 2445).
Shubeita et al., "Endothelin Induction of Inositol Phospholipid Hydrolysis, Sarcomere Assembly, and Cardiac Gene Expression in Ventricular Myocytes", J. Biol. Chem., 265(33):20555-20562, (1990).
Sil et al., "Myotrophin in Human Cardiomyopathic Heart", Circ. Res., 73(1):98-108, (1993).
Sil et al., "Role of Myotrophic in Pathophysiology of Cardiac Hypertrophy in Spontaneously Hypertensive Rat (SHR)", Circulation, 88(4 part 2):I-613, (1993) (abstract 3299).
Sil et al., "Purification of Myotrophin from Human Cardiomyopathic Heart", FASEB J. 5(5991):A1244, (1991) (abstract 5069).
Simpson et al., "Myocyte Hypertrophy in Neonatal Rat Heart Cultures and Its Regulation by Serum and by Catecholamines", Cir. Res., 51(6):787-801, (1982).
Simpson et al., "Differentiation of Rat Myoctyes in Single Cell Cultures with and without Proliferating Nonmyocardial Cells", Circ. Res., 50(1):101-116, (1982).
Suzuki et al., "Serum-Free, Chemically Defined Medium is Important to Investigate the Growth, Development and Function of Neonatal Rat Card

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cardiac hypertrophy factor and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cardiac hypertrophy factor and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cardiac hypertrophy factor and uses therefor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1868203

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.