Cardiac hypertrophy factor

Details Cardiac hypertrophy factor Cardiac hypertrophy factor

1994-08-05

1996-11-05

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530399, 530351, 930140, C07K 1452, A61K 3819

Patent

active

055718930

ABSTRACT:
Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

REFERENCES:
patent: 5141856 (1992-08-01), Collins et al.
Chien, "Molecular Advances in Cardiovascular Biology" Science 260:916-917 (May 14, 1993).
Jones et al., "Association Between Inhibition of Arachidonic Adic Release and Prevention of Calcium Loading During ATP Depletion in Cultured Rat Cardiac Myocytes" American Journal of Pathology 135(3):541-556 (1989).
Miller-Hance et al., "In Vitro Chamber Specification During Embroyonic Stem Cell Cardiogenesis" The Journal of Biological Chemistry 268(33) :25244-25252 (Nov. 25, 1993).
Pennica et al., "Expression Cloning of Cardiotrophin 1, a Cytokine That Induces Cardiac Myocyte Hypertrophy" Proceedings of the National Academy of Sciences, USA 92:1142-1146 (Feb. 1995).
McCornick et al J. Nutzition 119 1683-1690 (1989).

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