Cardiac glycosides inhibit proliferation of cells bearing FGF re

Details Cardiac glycosides inhibit proliferation of cells bearing FGF re Cardiac glycosides inhibit proliferation of cells bearing FGF re

1999-05-28

2000-08-22

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 27, 514 28, 514 29, 514 30, 514 31, 435184, 530351, 530396, 530399, A61K 31705, A01N 4500, C07K 100

Patent

active

061072834

ABSTRACT:
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta. and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.

REFERENCES:
patent: 5545623 (1996-08-01), Matsumori
patent: 5627195 (1997-05-01), Hu
patent: 5872103 (1999-02-01), Belletti
Katahira et al. Chemotherapy Jul. 1991, 39(7), 678-686.
Callard et al. "The Cytokine FactsBook" Academic Press Limited, London, 1994, pp. 31-38.

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