Cardiac glycoside enzyme conjugates

Details Cardiac glycoside enzyme conjugates Cardiac glycoside enzyme conjugates

1976-01-19

1977-08-02

Tanenholtz, Alvin E.

Textiles: fiber preparation

1951035R, C07G 702

Patent

active

040393852

ABSTRACT:
Enzyme conjugates are prepared of cardiac glycosides and aglycones for use in homogeneous enzyme immunoassays. The conjugates retain a substantial degree of the original activity of the enzyme and upon binding of receptor to the steroid moiety, a substantial diminution of enzyme activity is obtained. Various linking groups are employed for linking the steroid portion of the molecule to the enzyme, such as non-oxo carbonyl groups.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
Medical Pharmacology 7th Edition, p. 381 (1974).

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