Cardiac atrial peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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530325, C07K 712

Patent

active

046097252

ABSTRACT:
Monoiodinated-tyrosine derivatives of synthetic fragments of mammalian atrial natriuretic factor are biologically active and are useful to determine the mode of biological activity and the effect of derivatization on biological activity.

REFERENCES:
patent: 4448764 (1984-05-01), Smith et al.
patent: 4460559 (1984-07-01), Goldenberg
Gutkowska et al., Biochemical and Biophysical Research Communications, 122(2), 593-601, Jul. 31, 1984.
Kangawa et al., Biochemical and Biophysical Research Communications, 118(1), 131-139, Jan. 13, 1984.
Seidah et al., Proc. Natl. Acad. Sci., USA, 81, 2640-2644, May 1984.
Guttman, Calcitonin, 1980, Proceedings of an International Symposium held in Milan, Oct. 15-17, 1980.
Rittel et al., Experientia, 32(2), 246-248 (1976).

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