Cardiac arrhythmia treatment methods

Details Cardiac arrhythmia treatment methods Cardiac arrhythmia treatment methods

2006-04-25

2006-04-25

Ketter, James (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C604S528000

Reexamination Certificate

active

07034008

ABSTRACT:
Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical property of the heart. The methods have a wide variety of important uses including treating cardiac arrhythmia.

REFERENCES:
patent: 5163950 (1992-11-01), Pinchuk
patent: 5436128 (1995-07-01), Harpold et al.
patent: 5662585 (1997-09-01), Willis
patent: 5836905 (1998-11-01), Lemelson
patent: 5944710 (1999-08-01), Dev et al.
patent: 6086582 (2000-07-01), Altman et al.
patent: 6214620 (2001-04-01), Johns et al.
patent: 6309375 (2001-10-01), Glines
patent: 2003/0195470 (2003-10-01), Ponzi
patent: WO 96/28537 (1996-09-01), None
patent: WO 99/23880 (1999-05-01), None
patent: WO 00/18903 (2000-04-01), None
patent: WO 00/38518 (2000-07-01), None
patent: WO 00/41731 (2000-07-01), None
patent: WO 02/33111 (2002-04-01), None
Chen et al., Am J Physiol Heart Circ Physiol, vol. 280, H1989-H1995, 2001.
Bauer et al., Circulation, 110:3115-3120, 2004.
Schroder, Expert Opin. Biol. Ther., vol. 4, 9:1413-1422, 2004.
Donahue, J.K., et al., “Ultrarapid, Highly Efficient Viral Gene Transfer to the Heart”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 4664-4668, (Apr. 1997).
Donahue, J.K., et al., “Acceleration of Widespread Adenoviral Gene Transfer to Intact Rabbit Hearts by Coronary Perfusion With Low Calcium and Serotonin”, Gene Therapy, vol. 5, pp. 630-634, (1998).
Muhlhauser, J., et al., “Safety and Efficacy of In Vivo Gene Transfer Into the Porcine Heart with Replication-Deficient, Recombinant Adenovirus Vectors”, Gene Therapy, vol. 3, pp. 145-153, (1996).
French, B.A., et al., “Direct in Vivo Gene Transfer Into Porcine Myocardium Using Replication-Deficient Adenoviral Vectors”, Circulation, vol. 90, No. 5, pp. 2414-2424 (Nov. 1994).
Akhter, S.A., et al., “Restoration of β-adrenergic Signaling in Failing Cardiac Ventricular Myocytes via Adenoviral-mediated Gene Transfer”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 12100-12105, (Oct. 1997).
Donahue, J.K., et al., “Focal Modification of Electrical Conduction in the Heart by Viral Gene Transfer”, Nature Medicine, vol. 6, No. 12, pp. 1395-1398, (Dec. 2000).
Tomaselli, G.F., et al., “Electrophysiological Remodeling in Hypertrophy and Heart Failure”, Cardiovascular Research, vol. 42, pp. 270-283, (1999).
Marban, E., “Circulation Research Impact Factor Sets New Record”, Circulation Research, vol. 89, p. 101, (2001).
Lalli, M.J., et al., “Sarcoplasmic Reticulum Ca2+ATPase (SERCA) 1a Structurally Substitutes for SERCA2a in the Cardiac Sacroplasmic Reticulum and Increases Cardiac Ca2+Handling Capacity”, vol. 89, pp. 160-167, (2001).
Mazhari, R., et al., “Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized byIn VitroandIn SilicoAnalysis”, Circ. Res., vol. 89, pp. 33-38, (2001).
Sugiyama, A., et al., “Measurement of Adenylylcyclase Activity in the AV Nodal Region of the Canine Heart: Evidence for Inhibition by Adenosine and Acetylcholine”, Journal of Cardiovascular Pharmacology, vol. 29, pp. 734-739, (1997).
Yamagishi, T., et al., “Molecular Architecture of the Voltage-dependent Na Channel: Functional Evidence for a Helices in the Pore”, J. Gen. Physiol., vol. 118, pp. 171-181, (2001).
Seharaseyon, J., et al., “Molecular Composition of Mitochondrial ATP-Sensitive Potassium Channels Probed by Viral Kir Gene Transfer”, J. Mol. Cell Cardiol., vol. 32., pp. 1923-1930, (2000).
Kass-Eisler, A., et al., “Quantitative Determination of Adenovirus-Mediated Gene Delivery to Rat Cardiac MyocytesIn VitroandIn Vivo”, Proc. Natl. Acad. Sci. USA., vol. 90, pp. 11498-11502, (Dec. 1993).
Johns et al. “Adenovirus-Mediated Expression of a Voltage-Gated Potassium Channelin vitro(Rat Cardiac Myocytes) andin vivo(Rat Liver). A Novel Strategy For Modifying Excitability”, J. Clin. Invest. Aug. 1995, vol. 96, pp. 1152-1158.
Hoppe et al. “Adenovirus-Mediated Inducible Gene ExpressionIn VivoBy a Hybrid Ecdysone Receptor”, Molecular Therapy, Feb. 2000, vol. 1, No. 2, pp. 159-164.
Hoppe et al. “Molecular Dissection of Cardiac Repolarization ByIn VivoKv4.3 Gene Transfer”, Journal of Clinical Investigation, Apr. 2000, vol. 105, No. 8, pp. 1077-1084.
A copy of International Search Report dated Jun. 5, 2002 re corresponding International Application No. PCT/US01/27623, 4 pages.
Chiang C-E et al., The Long QT Syndromes: Genetic Basis and Clinical Implications,J. Amer. Coll. Cardiology, vol. 36, No. 1, Jul. 2000, pp. 1-12.
Gros DB et al., “Connexins in mammalian heart function,”Bioessays, vol. 18, No. 9, 1996, pp. 719-730.
Hajjar RJ et al., “Prospects for gene therapy for heart failure,”Circulation Research, vol. 86, No. 6, Mar. 31, 2000, pp. 616-621.
Hoppe Uta C et al., “Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes,”HERG and KCNE1 Proceedings of the National Academy of Sciences of the United States of America, vol. 98, No. 9, Apr. 24, 2001, pp. 5335-5340.
Johns, DC et al., “Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs,”J. Bio. Chem. vol. 272, No. 50 (Dec. 12, 1997), pp. 31598-31603.
Lawrence JH et al., “Prospects for genetic manipulation of cardiac excitability,”Advances in Experimental Medicine and biology, vol. 382, 1995, pp. 41-48.
Marban E. et al., “Gene Therapy for Cardiac Arrhythmias,”Cold Spring Harbor Symposia on Quantitative Biology, vol. 67, 2002, pp. 527-531.
Nuss HB et al., “Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes,”J. Clin. Invest. vol. 103, No. 6, Mar. 1999, pp. 889-896.
Nuss HB et al., “Reversal of Potassium Channel deficiency in Cells from Failing Hearts by Adenoviral Gene Transfer: A Prototype for Gene Therapy for Disorders of Cardiac Excitability and Contractility,”Gene Therapy, vol. 3, No. 3, Oct. 1996, pp. 900-912.

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