Cardiac anti-hypertrophic agents

Details Cardiac anti-hypertrophic agents Cardiac anti-hypertrophic agents

1985-01-22

1987-03-24

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, A61K 3702

Patent

active

046525491

ABSTRACT:
ANF and peptide subunits thereof and compounds having ANF-like activity have been found to reduce and reverse cardiac hypertrophy.

REFERENCES:
patent: 4496544 (1985-01-01), Needleman
Seidah et al., Proc. Natl. Acad. Sci., U.S.A., 81, 2640 (1984).
Chartier et al., Biochem. Biophys. Res. Comm., 122(1), 171-4 (1984).
Kangawa et al., Biochem. Biophy. Res. Communications, 118(1), 131-139 (1984).
Currie et al., Science, 221, 71-73 (1983).
Guttmann, Calcitonin 1980, Proceedings of International Sym. Milan, Oct. 15-17 (1980).
Rittet et al., Experientia, 32(2), 246 (1976).
Chemical Abstracts, 102, 132 (1985), Abst. No. 198634(a).

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