Card domain containing polypeptides, encoding nucleic acids,...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07626001

ABSTRACT:
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.

REFERENCES:
patent: 5223409 (1993-06-01), Ladner et al.
patent: 6858391 (2005-02-01), Nunez et al.
patent: 7083944 (2006-08-01), Bertin et al.
patent: WO 96/12016 (1996-04-01), None
patent: WO 99/40102 (1999-08-01), None
patent: WO 01/00826 (2001-01-01), None
patent: WO 01/18042 (2001-03-01), None
patent: WO 01/30971 (2001-05-01), None
patent: WO 01/66690 (2001-09-01), None
patent: WO 01/72822 (2001-10-01), None
Rost et al, “Enzyme function less conserved than anticipated”, Journal of Molecular Biology (2002) 318:595-608.
Dujon et al, Trends in Genetics (1996) 12(7):263-270.
Ahmad et al., “CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP,”Cancer Res. 57:615-619 (1997).
Altschul et al., “Gapped Blast and PSI-Blast: a new generation of protein database search programs,”Nucleic Acids Res., 25:3389-3402 (1997).
Bertin et al., “Human CARD4 Protein Is a Novel CED=4/Apaf-1 Cell Death Family Member That Activates Nf-kB,”Journal of Biological Chemistry274(19):12955-12958 (1999).
Bertin et al., “Human CARD4 Protein is a Novel CEO-4/Apaf-1 Cell Death Family Member that Activates Nf-kB*,”J. Biol. Chem. 274:12955-12958 (1999).
Damiano et al., “CLAN, a Novel Human CED-4-like Gene,”Genomics75:77-83 (2001).
DiDonato et al., “A cytokine-responsive IkB kinase that activates the transcription factor NF-kB,”Nature388:548-554 (1997).
Dujon, B., “The yeast genome project: what did we learn?”Trends Genet. 12(7):263-270 (1996).
Ellerby et al., “Anti-cancer activity of targeted pro-apoptotic peptides,”Nature Med. 5:1032-1038 (1999).
Enkhbayar et al., “Structural principles of leucine-rich repeat (LRR) proteins,”Proteins54:394-403 (2003).
Fletcher et al., “A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo,”J. Interferon Cytokine Res., 15:243-248 (1995).
Geddes et al., “Human CARD12 Is a Novel CED4/Apaf-1 Family Member That Induces Apoptosis,”Biochemical and Biophysical Research Communications284:77-82 (2001).
Gregoriadis,Liposome Technology, vols. I to III, 2nd ed., CRC Press, Boca Raton, FL (1993). (Table of contents only).
Hofmann and Bucher, “The CARD domain: a new apoptotic signalling motif,”Trends Biochem. Sci., 22:155-156 (1997).
Holinger et al., “Bak BH3 Peptides Antagonize Bcl-x.sub.L Function and Induce Apoptosis through Cytochrome c-independent Activation of Caspases,”J. Biol. Chem. 274:13298-13304 (1999).
Inohara et al., “Nodl, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-kB,”J. Biol. Chem. 274:14560-14567 (1999).
Kobe and Deisenhofer, “Proteins with leucine-rich repeats,”Current Opinion in Structural Biology, 3(5):409-416 (1995).
Koonin and Aravind, “The NACHT family—a new group of predicted NTPases implicated in apoptosis and MHC transcription activation,”Trends Biochem. Sci., 25(5):223-224 (2000).
Li et al., “Cytochrome c and dATP-Dependent Formation of Apaf-I/Caspase-9 Complex Initiate an Apoptotic Protease Cascase,”Cell91:479-489 (1997).
Neufeld and Rubin, “The Drosophila peanut Gene Is Required for Cytokinesis and Encodes a Protein Similar to Yeast Putative Bud Neck Filament Proteins,”Cell77:371-379 (1994).
Ogura et al., “Nod2, a Nodl/Apaf-1 family member that is restricted to monocytes and activates Nf-.kappa.B”,J. of Biol. Chem. 276 (7):4812-4818 (2001).
Poyet et al., “Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1,”Journal of Biological Chemistry276:28309-28313 (2001).
Rano et al., “A combinatorial approach for determining protease specificities: application to interleukin-1 beta converting enzyme (ICE),”Chem. Biol., 4:149-155 (1997).
Rodriguez et al., “Dark is a Drosophila homologue of Apaf-1/CEO-4 and functions in an evolutionarily conserved death pathway,”Nature Cell Biol. 1:272-279 (1999).
Rost et al, “Enzyme function less conserved than anticipated”,Journal of Molecular Biology, 318:595-608 (2002).
Rothe et al., “The TNFR2-TRAF Signaling Complex Contains Two Novel Proteins Related to Baculoviral Inhibitor of Apoptosis Proteins,”Cell83:1243-1252 (1995).
Rotonda et al., “The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis,”Nature Struc. Biol. 3:619-625 (1996).
Rychlewski et al., “Comparison of sequence profiles. Strategies for structural predictions using sequence information,”Protein Science9:232-241 (2000).
Saleh et al., “Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation,”J. Biol. Chem. 274:17941-17945 (1999).
Schwarze et al., “In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse,”Science285:1569-1572 (1999).
Stapleton et al., “The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization,”Nature Structural Biology6(1):44-49 (1999).
Tatusova and Madden, “Blast 2 Sequences, a new tool for comparing protein and nucleotide sequences,”FEMS Microbiol Lett. 174:247-250 (1999).
Thome et al., “Identification of CARDIAK, a RIP-like kinase that associates with caspase-1,”Curr. Biol. 8:885-888 (1998).
Thornberry and. Molineaux, “Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death,”Protein Sci., 4:3-12 (1995).
Thornberry et al., “A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes,”Nature, 356:768-774 (1992).
Thornberry, Nancy A., “Caspases: key mediators of apoptosis,”Chemistry and Biology5:R97-R103 (1998).
Tschopp et al., “Inhibition of Fas death signals by FLIPs,”Curr. Op. Immunol. 10:552-558 (1998).
van der Biezen and Jones, “The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals,”Curr. Biol. 8:R226-R227 (1998).
Vocero-Akbani et al., “Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein,”Nature Med. 5:29-33 (1999).
Willis et al., “Bc110 is Involved in t(1;14) (p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types,”Cell96:35-45 (1999).
Yuan and Horvitz, “The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death,”Development116:309-320 (1992).
Zou et al., “An APAF-1 Cytochrome c Multimeric Complex is a Functional Apoptosome that Activates Procaspase-9,”J. Biol. Chem. 274:11549-11556 (1999).
Zou et al., “Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c-Dependent Activation of Caspase-3,”Cell90:405-413 (1997).
Database Accession No. AC007728, Database EMBL, “Homo sapienschromosome 16 clone RP11-327f22, complete sequence” (Jun. 7, 1999).
Database Accession No. AC010968, Database EMBL, “Homo sapienschromosome 2 clone RP11-9302, Working Draft Sequence, 11 unordered pieces” (Sep. 29, 1999).
Database Accession No. AC016492, Database EMBL, “Homo sapienschromosome 4 clone RP11-94C22 map 4, Low-Pass Sequence Sampling” (Dec. 10, 1999).
Database Accession No. AC025758, Database EMBL, “Homo sapienschromosome 5 clone CTD-2235A13, Working Draft Sequence, 16 ordered

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Card domain containing polypeptides, encoding nucleic acids,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Card domain containing polypeptides, encoding nucleic acids,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Card domain containing polypeptides, encoding nucleic acids,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4081353

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.