Card domain containing polypeptides, encoding nucleic acids,...

Details Card domain containing polypeptides, encoding nucleic acids,... Card domain containing polypeptides, encoding nucleic acids,...

2007-03-27

2007-03-27

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120

Reexamination Certificate

active

09864921

ABSTRACT:
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.

REFERENCES:
patent: 5223409 (1993-06-01), Ladner et al.
patent: WO 96/12016 (1996-04-01), None
patent: WO 99/40102 (1999-08-01), None
patent: WO 01/00826 (2001-01-01), None
patent: WO 01/18042 (2001-03-01), None
patent: WO 01/30971 (2001-05-01), None
patent: WO 01/66690 (2001-09-01), None
patent: WO 01/72822 (2001-10-01), None
Rost et al, “Enzyme function less conserved than anticipated”, Journal of Molecular Biology (2002) 318:595-608.
Genbank Accession No. AQ309404 (Dec. 22, 1998).
Dujon et al, Trends in Genetics (1996) 12(7):263-270.
Ahmad et al., “CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP,”Cancer Res. 57:615-619 (1997).
Altschul et al., “Gapped Blast and PSI-Blast: a new generation of protein database search programs,”Nucleic Acids Res., 25:3389-3402 (1997).
Bertin et al., “Human CARD4 Protein is a Novel CEO-4/Apaf-1 Cell Death Family Member that Activates NF-kB*,”J. Biol. Chem. 274:12955-12958 (1999).
DiDonato et al., “A cytokine-responsive IkB kinase that activates the transcription factor NF-kB,”Nature388:548-554 (1997).
Ellerby et al., “Anti-cancer activity of targeted pro-apoptotic peptides,”Nature Med. 5:1032-1038 (1999).
Fletcher et al., “A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta productionin vitroandin vivo,” J. Interferon Cytokine Res., 15:243-248 (1995).
Gregoriadis, Liposome Technology, vols. I to III, 2nd ed., CRC Press, Boca Raton FL (1993). (Table of contents only).
Hofmann et al., “The CARD domain: a new apoptotic signalling [sic] motif,”Trends Biochem. Sci. 22:155-156 (1997).
Holinger et al., “Bak BH3 Peptides Antagonize Bcl-xLFunction and Induce Apoptosis through Cytochromec-independent Activation of Caspases,”J. Biol. Chem. 274:13298-13304 (1999).
Inohara et al., “Nodl, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-kB,”J. Biol. Chem. 274:14560-14567 (1999).
Li et al., “Cytochrome c and dATP-Dependent Formation of Apaf-l/Caspase-9 Complex Initiate an Apoptotic Protease Cascase,”Cell91:479-489 (1997).
Neufeld and Rubin, “The DrosophilapeanutGene Is Required for Cytokinesis and Encodes a Protein Similar to Yeast Putative Bud Neck Filament Proteins,”Cell77:371-379 (1994).
Ogura et al., “Nod2, a Nodl/Apaf-1 family member that is restricted to monocytes and activates Nf-κB”,J. of Biol. Chem. 276 (7):4812-4818 (2001).
Rano et al., “A combinatorial approach for determining protease specificities: application to interleukin-1 beta converting enzyme (ICE),”Chem. Biol., 4:149-155 (1997).
Rodriguez et al., “Dark is aDrosophilahomologue of Apaf-1/CEO-4 and functions in an evolutionarily conserved death pathway,”Nature Cell Biol. 1:272-279 (1999).
Rothe et al., “The TNFR2-TRAF Signaling Complex Contains Two Novel Proteins Related to Baculoviral Inhibitor of Apoptosis Proteins,”Cell83:1243-1252 (1995).
Rotonda et al., “The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis,”Nature Struc. Biol. 3:619-625 (1996).
Saleh et al., “Cytochromecand dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation,”J. Biol. Chem. 274:17941-17945 (1999).
Schwarze et al., “In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse,”Science285:1569-1572 (1999).
Tatusova and Madden, “Blast 2 Sequences, a new tool for comparing protein and nucleotide sequences,”FEMS Microbiol Lett. 174:247-250 (1999).
Thome et al., “Identification of CARDIAK, a RIP-like kinase that associates with caspase-1,”Curr. Biol. 8:885-888 (1998).
Thornberry, Nancy A., “Caspases: key mediators of apoptosis,”Chemistry and Biology5:R97-R103 (1998).
Thornberry et al., “A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes,”Nature, 356:768-774 (1992).
Thornberry and. Molineaux, “Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death,”Protein Sci., 4:3-12 (1995).
Tschopp et al., “Inhibition of Fas death signals by FLIPs,”Curr. Op. Immunol. 10:552-558 (1998).
van der Biezen and Jones, “The NB-ARC domain: a novel signalling [sic] motif shared by plant resistance gene products and regulators of cell death in animals,”Curr. Biol. 8:R226-R227 (1998).
Vocero-Akbani et al., “Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein,”Nature Med. 5:29-33 (1999).
Willis et al., “Bc110is Involved in t(1;14) (p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types,”Cell96:35-45 (1999).
Yuan and Horvitz, “TheCaenorhabditis eleganscell death geneced-4encodes a novel protein and is expressed during the period of extensive programmed cell death,”Development116:309-320 (1992).
Zou et al., “Apaf-1, a Human Protein Homologous toC. elegansCED-4, Participates in Cytochrome c-Dependent Activation of Caspase-3,”Cell90:405-413 (1997).
Zou et al., “An APAF-1 CytochromecMultimeric Complex is a Functional Apoptosome that Activates Procaspase-9,”J. Biol. Chem. 274:11549-11556 (1999).
GenBank: AC008810.
GenBank: AC007728.
GenBank: NT-002476.
GenBank: AC010968.
GenBank: AP001153.
GenBank: AC022468.
GenBank: AP000799 (withdrawn).
GenBank: AC023068.
GenBank: W58453.
GenBank: AA257158.
GenBank: AA046000.
GenBank: AW085161.
GenBank: AI189838.
GenBank: AA418021.
GenBank: AA046105.
GenBank: W58488.
GenBank: AA418193.
GenBank: AA257066.
GenBank: BAA14061.1.
GenBank: AP000658.
Hofmann and Bucher, “The card domain: a new apoptotic signalling motif,”TIBS, 22:155-156 (1997).
Genbank accession No. AC025758.
Genbank accession No. AC016492.
Genbank accession No. AC026732.
Bertin et al., “Human CARD4 Protein Is a Novel CED=4/Apaf-1 Cell Death Family Member That Activates Nf-kB,”Journal of Biological Chemistry274(19):12955-12958 (1999).
Damiano et al., “CLAN, a Novel Human CED-4-like Gene,”Genomics75:77-83 (2001).
Geddes et al., “Human CARD12 Is a Novel CED4/Apaf-1 Family Member That Induces Apoptosis,”Biochemical and Biophysical Research Communications284:77-82 (2001).
Hofmann et al., “The CARD domain: a new apoptotic signalling motif,”TIBS22(5):155-156 (1997).
Kobe and Deisenhofer, “Proteins with leucine-rich repeats,”Current Opinion in Structural Biology, 3(5):409-416 (1995).
Koonin and Aravind, “The NACHT family—a new group of predicted NTPases implicated in apoptosis and MHC transcription activation,”TIBS25(5):223-224 (2000).
Ogura et al., “Nod2, a Nod1/Apag-1 Family Member That Is Restricted to Monocytes and Activates NF-kB,”Journal of Biological Chemistry276(7):4812-4818 (2001).
Poyet et al., “Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1,”Journal of Biological Chemistry276:28309-28313 (2001).
Rychlewski et al., “Comparison of sequence profiles. Strategies for structural predictions using sequence information,”Protein Science9:232-241 (2000).
Stapleton et al., “The crystal structure of an Eph receptor SAM domain reveals a mechansim for modular dimerization,”Nature Structural Biology6(1):44-49 (1999).
Database Accession No. AC007728, DATABASE EMBL, “Homo sapienschromosome 16 clone RP11-327f22, complete sequence” (Jun. 7, 1999).
Database

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