Carcinostatic for hormonotherapy containing dienogest as effecti

Details Carcinostatic for hormonotherapy containing dienogest as effecti Carcinostatic for hormonotherapy containing dienogest as effecti

1994-11-16

1997-07-29

Goldberg, Jerome

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3156

Patent

active

056522312

ABSTRACT:
A carcinostatic for a hormonotherapy containing dienogest or its solvate, which is expected to exert therapeutic effects for a broad range of cancer cases at a far lower dose than that of conventional hormonotherapeutic agents and utterly free from side effects that the conventional high-dose hormonotherapy had suffered. ##STR1##

REFERENCES:
Nikschick et al., Exp. Clin. Endocrinol, (Sep. 1989) vol. 94 (1-2) pp. 211-214.
"Endometriosetherapie Mit Dienogest" by G. Kohler et al., Zent. BL. Gynakol, vol. 109, No. 12, 1987, pp. 795-801. Abstract only.
Ishizaki et al. Acta Obst. Gynec Jpn., vol. 44, No. 1, pp. 67-72 (1992) Abstract only.
Morisawa et al., J. Jpn. Soc. Clin. Cytol., vol. 26, No. 3, pp. 433-442 (May 1987). Summary only.
"Synthesis, Effects, and Metabolism of the Progestagen and Potential Interceptive Dienogest" by K. Schubert et al. Natural Products Chemistry, 1984, pp. 143-158.
"Martindale, The Extra Pharmacopoeia" edited by J.E.F. Reynolds, The Pharmaceutical Press, 1989, pp. 1386-1387.
"Progestational Agents in the Treatment of Breast Cancer", Cancer Treat Res., vol. 39, 1988, pp. 147-157.
"Lipid Metabolism During Treatment of Endometriosis with the Progestin Dienogest" by G. Kohler et al, Acta Obstetricia et Gynecologica Scandinavica, vol. 68, No. 7, 1989, pp. 633-635.

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