Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1977-12-20
1980-04-01
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
424251, 544313, A61K 31505
Patent
active
041962028
ABSTRACT:
Carcinostatic composition containing an oily substance such as a glyceride and 3-N-o-toluyl-5-fluorouracil suspended therein. The composition exhibits a remarkable carcinostatic effect against various cancerous cells at a low dose and has less side-effects than 5-fluorouracil and its known derivatives which have been typical carcinostatic compounds. A process of producing carcinostatic composition comprises dispersing 1,3-di-N-acyl-5-fluorouracil into an oily substance such as a glyceride to prepare an emulsion and selectively substituting a hydrogen atom only for the 1-position acyl group, whereby the compound is acylated only at the 3-position and which is a chief constituent of the carcionstatic composition.
REFERENCES:
patent: 4088646 (1978-05-01), Ishida et al.
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